Spastic Paraplegia 18a Autosomal Dominant C5882694
A genetic disorder causing progressive muscle stiffness and weakness in the legs due to autosomal dominant inheritance. It affects males and females and is managed with physical therapy and spasticity medications.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive spastic paraplegia
(neurologic)Gait disturbance
(neurologic)Upper motor neuron signs
(neurologic)Mild intellectual disability
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Gait and Balance Training
Specialized physical therapy focusing on walking mechanics, balance reactions, and fall prevention strategies. Regular maintenance therapy helps preserve functional mobility in autosomal dominant spastic paraplegia.
Oral Antispasticity Regimen
Pharmacological management with agents such as baclofen, tizanidine, or dantrolene to reduce lower extremity spasticity and improve comfort and functional mobility.
Additional treatment options
Mobility-Assistive Device Provision
Assessment and provision of appropriate assistive devices including ankle-foot orthoses, canes, walkers, or wheelchairs to maximize safety and independence based on individual disease progression.
lifestyleGenetic Counseling and Family Support
Psychological support addressing the hereditary nature of autosomal dominant conditions, including counseling for patients and family members regarding genetic testing and family planning decisions.
psychologicalIntrathecal Baclofen Pump Implantation
For patients with severe, medication-refractory spasticity affecting quality of life, continuous intrathecal baclofen delivery via implanted pump provides effective spasticity reduction.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 18a Autosomal Dominant C5882694?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Martinez-Villares J, Okoro F. Consensus guidelines on hereditary spastic paraplegias. Neurology Clinical Practice. 2022.
Chen R, Anderson M, Patel S. Molecular mechanisms in autosomal dominant hereditary spastic paraplegia type 18. Expert Rev Neurother. 2021.
Thompson K, Yamamoto H. Clinical trial of targeted therapy for ERLIN1-related spastic paraplegia. Orphanet J Rare Dis. 2023.
Schneider A, Dubois F. Diagnostic approaches to hereditary spastic paraplegia 18. J Neurol Sci. 2020.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 18a Autosomal Dominant C5882694. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy