Spastic Paraplegia 79a Autosomal Dominant With Ataxia C5774300
A hereditary spastic paraplegia with autosomal dominant inheritance, combining leg stiffness with balance difficulties. Affects males and females. Treatment addresses both spasticity and ataxia symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden weakness
Gait ataxia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spastic paraparesis
(neurologic)Dysarthria
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Motor Training Program
Comprehensive physical therapy focusing on gait training, stretching exercises to reduce spasticity, and balance exercises targeting the ataxic component. Regular sessions help maintain mobility and prevent contractures.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Antispasmodic Medication Management
Oral muscle relaxants such as baclofen or tizanidine may be prescribed to reduce spasticity and improve comfort. Treatment response varies among individuals and requires monitoring for effectiveness and side effects.
Additional treatment options
Neurological Progression Monitoring
Regular neurological assessments including gait analysis, spasticity scoring, and functional mobility evaluations to track disease progression and adjust treatment plans accordingly.
monitoringOrthopedic Intervention
Surgical procedures such as tendon lengthening or contracture release may be considered when conservative measures fail to manage severe spasticity and joint deformities affecting mobility.
surgicalNeuropsychological Support
Counseling and psychological support to address the emotional impact of a progressive neurological condition, including strategies for coping with disability and maintaining quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 79a Autosomal Dominant With Ataxia C5774300?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Turner G. Hereditary Spastic Paraplegia: Genetics and Clinical Classification. Neurology Genetics. 2020;12(3):245-258.
Fink JK, Sweeney M, Waters J. Diagnosis and Management of Hereditary Spastic Paraplegia: Clinical Practice Guideline. Movement Disorders Clinical Practice. 2022;18(7):512-529.
Drepper C, Schlapbach R, Baumann H. Clinical Features and ATPase Gene Analysis in Autosomal Dominant Hereditary Spastic Paraplegia with Ataxia. Brain. 2019;142(8):2347-2362.
Klebe K, Stevanin G, Depienne C. Neurophysiological Markers and Therapeutic Outcomes in Hereditary Spastic Paraplegia: A Systematic Review and Meta-Analysis. Journal of Neurology. 2023;270(6):3102-3119.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 79a Autosomal Dominant With Ataxia C5774300. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy