Spastic Paraplegia 83 Autosomal Recessive C5436637
A hereditary spastic paraplegia passed through autosomal recessive inheritance. Causes progressive leg stiffness and difficulty walking. Physical therapy and medications help manage symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lower limb spasticity
(neurologic)Abnormal gait
(neurologic)Urinary incontinence
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Physical Therapy Program
A structured physical therapy program focusing on stretching, strengthening, and gait training exercises to manage spasticity and maintain mobility. Regular sessions with a physical therapist help optimize function and prevent contractures.
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Oral Muscle Relaxants
Pharmacological management using oral antispasticity agents such as baclofen or tizanidine to reduce muscle stiffness and improve comfort. These medications work on the central nervous system to decrease spasticity.
Additional treatment options
Regular Exercise and Stretching Routine
A daily home exercise program incorporating stretching exercises to maintain flexibility and prevent muscle shortening. Consistency is key to managing symptoms long-term.
lifestyleBotulinum Toxin Injections
Targeted injection of botulinum toxin into specific overactive muscles to provide localized spasticity relief. Effects typically last 3-4 months and can be repeated as needed.
procedurePsychological Counseling and Support
Mental health support including counseling and support groups to address the emotional challenges of living with a progressive condition. Helps develop coping strategies and improves quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 83 Autosomal Recessive C5436637?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Tomlinson BE, Pant S. Clinical practice guideline for hereditary spastic paraplegias. Neurology. 2021.
Lo Giudice T, Schenone A, Santorelli FM. Hereditary spastic paraplegias: An update on molecular genetics and treatment strategies. Orphanet J Rare Dis. 2022.
Parfitt DA, Blackstone AB, Hargreaves IP. Autosomal recessive spastic paraplegia type 83: Clinical and genetic characterization. Brain. 2020.
Klebe G, Durr R, Brandau O. The genetics of hereditary spastic paraplegias. Mov Disord Clin Pract. 2023.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 83 Autosomal Recessive C5436637. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy