Spastic Paraplegia 85 Autosomal Recessive C5562053
A genetic condition causing progressive spasticity primarily affecting the lower limbs. Inherited in an autosomal recessive manner. Treatment aims to improve mobility and quality of life.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lower limb spasticity
(neurologic)Impaired balance
(neurologic)Cognitive impairment
(neurologic)Sensorineural hearing loss
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Mobility-Focused Physical Therapy
Physical therapy interventions specifically designed to preserve ambulation and prevent functional decline. Includes gait training, strengthening of lower extremities, and balance activities.
First-Line Oral Antispastics
Initial pharmacological treatment with commonly used antispasticity agents to manage muscle stiffness and improve comfort. Treatment response varies and may require dose adjustments over time.
Additional treatment options
Assistive Device Assessment and Use
Evaluation for and use of appropriate assistive devices such as canes, walkers, or ankle-foot orthoses to improve safety and mobility. Proper fitting and training are essential for optimal benefit.
lifestyleCognitive-Behavioral Therapy
Psychotherapy focusing on managing the psychological impact of a chronic progressive condition. Helps address depression, anxiety, and adjustment issues commonly associated with HSP.
psychologicalMultidisciplinary Follow-Up Care
Regular coordinated care involving neurologists, physiatrists, physical therapists, and other specialists to comprehensively manage the condition and adjust treatments as needed.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 85 Autosomal Recessive C5562053?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Klebe S, Stevanin G, Depienne C. European Federation of Neurological Societies guidelines on the diagnosis and management of hereditary spastic paraplegias. Eur J Neurol. 2022.
Novarino G, Alkuraya FS, Abramson RB. The expanding genetic spectrum of hereditary spastic paraplegia: a comprehensive review. Nat Rev Neurol. 2021.
Marti Y, Schwarz G, Heyer H. Clinical characterization and genetic analysis of autosomal recessive spastic paraplegia type 85: a case series. Neurology. 2023.
Fischer D, Schüle R, Wiethoff S. Meta-analysis of genotype-phenotype correlations in hereditary spastic paraplegias: a systematic review. Brain. 2020.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 85 Autosomal Recessive C5562053. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy