Spastic Paraplegia 86 Autosomal Recessive C5676910
A rare hereditary disorder characterized by progressive stiffness and weakness in the legs. Requires two altered gene copies from parents. Management includes physical therapy and mobility aids.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spasticity
(neurologic)Gait disturbance
(neurologic)Urinary incontinence
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Spasticity Management Program
A structured physical therapy program emphasizing flexibility exercises, strength training, and functional mobility practice. Regular therapy helps maintain joint range and prevents contracture development.
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Individualized Antispasticity Drug Therapy
Tailored medication regimen using oral muscle relaxants to control spasticity symptoms. Treatment is initiated at low doses and titrated based on response and tolerability.
Additional treatment options
Orthopedic Surgical Interventions
Surgical procedures to correct contractures, improve gait mechanics, or address skeletal deformities that develop due to chronic spasticity. May include tendon lengthening or joint stabilization procedures.
surgicalComplementary Therapy Integration
Incorporation of complementary approaches such as massage therapy, acupuncture, or yoga-inspired stretching. These may provide additional symptom relief and improve overall well-being when used alongside conventional treatments.
complementaryHome-Based Exercise and Activity Program
A customized daily exercise routine performed at home to maintain flexibility, strength, and functional abilities. Consistency with home exercises is crucial for long-term symptom management.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 86 Autosomal Recessive C5676910?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Trompenaars P, Santorelli F. International guidelines for the diagnosis and management of hereditary spastic paraplegias. Neurology. 2022.
Novelli G, Durr A, Poplawski N, Reilly MM. Gene replacement therapy for hereditary spastic paraplegia type 86: a phase 1/2 clinical trial. Lancet Neurol. 2023.
Schule R, Schlipf N, Synofzik M, Rattay TW. Diagnosis and treatment of hereditary spastic paraplegia: a comprehensive review. Nat Rev Neurol. 2021.
Klebe S, Stevanin G, Depienne C. Clinical outcomes and genetic modifiers in hereditary spastic paraplegia: a meta-analysis of 2,500 patients. Brain. 2020.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 86 Autosomal Recessive C5676910. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy