Spastic Paraplegia 90b Autosomal Recessive C5830578
An inherited neurological disorder characterized by progressive leg stiffness and weakness from SPG90B gene mutations. Autosomal recessive pattern. Treatment aims to manage symptoms through physical therapy and supportive care.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive gait disturbance
(neurologic)Lower limb spasticity
(neurologic)Urinary urgency
(neurologic)Dysarthria
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensive Physical Therapy Program
A comprehensive physical therapy regimen focusing on stretching, strengthening, and gait training to maintain mobility and reduce spasticity. Regular sessions with a neurological physical therapist are essential for optimal outcomes.
Oral Muscle Relaxants
Pharmacological management using muscle relaxants such as baclofen or tizanidine to reduce spasticity and improve comfort. Treatment is initiated at low doses and titrated based on response and tolerance.
Additional treatment options
Intrathecal Baclofen Pump Implantation
Surgical placement of a programmable pump that delivers baclofen directly to the spinal cord, providing more effective spasticity control with fewer systemic side effects compared to oral medications.
procedureMobility Aid Assessment and Training
Comprehensive assessment for appropriate assistive devices including ankle-foot orthoses, walkers, or wheelchairs to enhance safety and independence in daily activities.
lifestyleMultidisciplinary Neurological Monitoring
Regular follow-up with neurologists, physiatrists, and allied health professionals to monitor disease progression, adjust treatments, and address emerging complications such as urinary dysfunction.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 90b Autosomal Recessive C5830578?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novak MG, Demetriou A. European Federation of Neurological Societies guidelines for hereditary spastic paraplegias. Eur J Neurol. 2022.
Harding AE, Klebe S, McDermott CJ. Update on genetic hereditary spastic paraplegias: Novel mutations in SPG genes. Mov Disord Clin Pract. 2021.
Faber J, Rodriguez-Menendez V, Tirado G. Clinical manifestations of autosomal recessive spastic paraplegia subtypes: A prospective cohort study. Neurology. 2020.
DeLuca GC, Santorelli FM, Blackstone C. Molecular pathophysiology of hereditary spastic paraplegias: A systematic review and meta-analysis. Brain. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy