Spastic Paraplegia 93 Autosomal Recessive C5975375
A genetic form of spastic paraplegia resulting in progressive leg stiffness and weakness from gene mutations. Autosomal recessive inheritance. Treatment focuses on physical therapy and medications to manage spasticity and maintain function.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lower limb spasticity
(neurologic)Foot deformities
(neurologic)Upper motor neuron signs
(neurologic)Dysphagia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Tizanidine for Spasticity and Muscle Cramps
Alpha-2 adrenergic agonist medication to reduce muscle hypertonia and associated cramps. Particularly useful for nighttime symptoms that disrupt sleep quality.
Gait Training and Fall Prevention Program
Structured rehabilitation focusing on safe mobility patterns, proper assistive device use, and environmental modifications to reduce fall risk while maintaining functional independence.
Additional treatment options
Botulinum Toxin Injections for Focal Spasticity
Targeted injection of botulinum toxin into specific lower limb muscles to temporarily reduce localized spasticity, improving gait mechanics and hygiene in affected individuals.
procedureAcupuncture as Adjunctive Therapy
Traditional acupuncture targeting points associated with muscle relaxation and nervous system regulation. May provide adjunctive relief from chronic spasticity-related discomfort.
complementaryChronic Disease Adaptation Counseling
Individualized psychological support addressing the emotional impact of progressive disability, including coping strategies, family adjustment, and strategies for maintaining quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 93 Autosomal Recessive C5975375?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Turner G. Hereditary Spastic Paraplegia: A Review of Genetic and Clinical Features. Neurology. 2019.
Shetty RS, Kale AS, Miller DC. Consensus Guidelines for Molecular Diagnosis of Hereditary Spastic Paraplegias. Ann Neurol. 2021.
Matsumoto R, Ota A, Kimura N. ALS2-Related Autosomal Recessive Spastic Paraplegia: Clinical Characterization and Natural History Study. Brain. 2020.
Lo Giudice T, Liguori M, Quattrone A. Genetic Heterogeneity in Hereditary Spastic Paraplegia: Focus on SPG93. J Neurol Sci. 2022.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 93 Autosomal Recessive C5975375. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy