Spermatogenic Failure 6 C4225503
A genetic condition causing male infertility due to impaired sperm production. It results from specific gene mutations affecting sperm development. Assisted reproductive technologies may help achieve pregnancy.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility
(reproductive)Low libido
(reproductive)Scrotal pain
(reproductive)Testicular atrophy
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Intracytoplasmic Sperm Injection (ICSI)
ICSI involves direct injection of a single sperm into an oocyte and represents the most effective assisted reproductive technology for male factor infertility. Combined with IVF, it bypasses impaired sperm function and transport.
Fertility Counseling and Support
Specialized psychological support addresses the emotional impact of infertility diagnosis including stress, anxiety, depression, and relationship strain. Counseling helps couples navigate complex treatment decisions and expectations.
Additional treatment options
Empirical Hormone Therapy
Clomiphene citrate or letrozole may be trialed to potentially improve sperm production through gonadotropin stimulation. While evidence is limited for genetic causes, hormonal therapy may provide modest benefit in some cases.
medicationMicrosurgical Sperm Retrieval
Microdissection testicular sperm extraction (micro-TESE) retrieves sperm directly from testicular tissue for use in ICSI. Indicated when no sperm are present in ejaculate. May be combined with fresh or cryopreserved use.
surgicalAntioxidant Supplementation
Antioxidant combinations including vitamin E, vitamin C, selenium, coenzyme Q10, and zinc may modestly improve sperm parameters. Reduces oxidative stress which can damage sperm DNA and function.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 6 C4225503?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Cioppi F, Riera-Escandon L. Genetic factors of non-obstructive azoospermia: Consequences for clinical management. Hum Reprod Update. 2022.
American Urological Association. The Evaluation of the Azoospermic Male: AUA Guideline. J Urol. 2020.
Wang M, Liu M, Sun J, et al. Novel biallelic SPEM1 mutations cause male infertility with asthenozoospermia. Andrology. 2021.
Tüttelmann F, Ruckert C, Röpke A. Disorders of spermatogenesis: Perspectives for novel genetic diagnostics. Mol Hum Reprod. 2018.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 6 C4225503. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy