Spermatogenic Failure 71 C5676963
A genetic condition affecting sperm development in males, resulting in infertility. It's caused by mutations in specific genes involved in sperm production. Assisted reproduction may be an option.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe oligospermia
(reproductive)Poor sperm motility
(reproductive)Increased sperm DNA fragmentation
(reproductive)Testicular pain or discomfort
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aromatase inhibitor therapy
Use of anastrozole or letrozole to reduce estrogen and increase testosterone levels. Aromatase inhibitors block conversion of testosterone to estrogen, addressing elevated estrogen-to-testosterone ratios seen in some infertile men.
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Moderate exercise program
Structured physical activity program combining aerobic exercise (150 minutes weekly) with resistance training. Regular exercise improves hormonal balance, reduces adipose tissue estrogen production, and enhances overall metabolic health.
Additional treatment options
Subinguinal microsurgical varicocelectomy
Microsurgical repair of varicocele through a small subinguinal incision with optical magnification. This technique preserves testicular arteries and lymphatics while ligating incompetent veins.
surgicalMediterranean-style diet
Anti-inflammatory dietary pattern emphasizing omega-3 fatty acids, fresh vegetables, whole grains, and lean proteins while limiting processed foods. This reduces systemic inflammation that may impair spermatogenesis.
dietarySerial semen analysis and hormone panels
Regular monitoring of semen parameters (concentration, motility, morphology) and serum hormones (FSH, LH, testosterone, estradiol) to track disease progression and treatment response. Enables evidence-based treatment adjustments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 71 C5676963?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jungwirth A, Giwercman A, Tournaye H, et al. European Association of Urology Guidelines on Male Infertility: The 2022 Update. Eur Urol. 2022.
Krausz C, Cioppi F, Riera-Escandon L. Genetic Factors of Non-Obstructive Azoospermia: Consequences for Clinical Management. Andrology. 2020.
Tüttelmann F, Ruckert C, Röpke A, et al. Disorders of Spermatogenesis: Perspectives for Novel Genetic Diagnostics After 20 Years of Mandatory ACMG Reporting. Hum Genet. 2021.
Vasseur C, Gmys T, Hesters L, et al. Molecular Mechanisms Underlying Spermatogenic Failure in Men With Genetic Disorders. Mol Hum Reprod. 2023.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 71 C5676963. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy