Spermatogenic Failure 82 C5830468
A genetic condition impairing sperm production in the testes, leading to male infertility. Treatment options may include assisted reproductive technologies.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility
(reproductive)Low semen volume
(reproductive)Decreased libido
(reproductive)Testicular atrophy
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aromatase Inhibitor Therapy
Aromatase inhibitors such as anastrozole reduce estrogen and increase testosterone-to-estradiol ratio. This treatment addresses hormonal imbalances that impair spermatogenesis, particularly in obese men with elevated estrogen.
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Weight Loss and Metabolic Optimization
Structured weight loss program addressing obesity-related hormonal disruption including reduced testosterone and elevated SHBG. Weight reduction improves hormonal profiles and may restore natural spermatogenesis.
Additional treatment options
Smoking Cessation
Comprehensive smoking cessation program addressing tobacco's detrimental effects on sperm DNA integrity and motility. Smoking contributes to oxidative stress and testicular dysfunction.
lifestyleStress Management and Counseling
Psychological support addressing the emotional impact of infertility diagnosis and treatment. Stress reduction techniques may improve hormonal balance and treatment adherence.
psychologicalScrotal Cooling Therapy
Application of scrotal cooling devices or cold packs to lower testicular temperature, which can improve sperm production. Regular use may benefit men with occupational heat exposure.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 82 C5830468?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
WHO Human Reproduction Programme. Guidelines on the management of male factor infertility. Int J Androl. 2023.
Krausz C, Ch够-Müller R. Genetic basis of male infertility: focus on spermatogenic failure. Hum Reprod Update. 2021.
Tüttelmann F, Ruckert C, Römer S. Clinical outcomes of intracytoplasmic sperm injection in men with genetic spermatogenic defects. Andrology. 2022.
Santi D, Magnani E, De Vincentis S. Management of non-obstructive azoospermia: a systematic review and meta-analysis. Eur Urol. 2020.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 82 C5830468. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy