Spermatogenic Failure 83 C5830470
A genetic subtype of male infertility affecting sperm development. Fertility specialists can discuss options like IVF or ICSI.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility
(reproductive)Oligospermia
(reproductive)Reduced sperm motility
(reproductive)Testicular atrophy
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combined Gonadotropin Therapy
Combination therapy with hCG and FSH provides comprehensive stimulation of testicular function. This approach mimics physiological gonadotropin secretion and supports the entire spermatogenic cycle.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
IVF/ICSI Treatment Planning
Comprehensive assisted reproductive technology planning including sperm retrieval, in vitro fertilization, and intracytoplasmic sperm injection. ICSI enables fertilization even with severely impaired sperm parameters.
Additional treatment options
Microsurgical Reconstruction
Reconstructive surgery for obstructive causes such as epididymal obstruction or vasal agenesis. Vasovasostomy or epididymovasostomy may restore natural sperm passage.
surgicalSelective Estrogen Receptor Modulators
Tamoxifen therapy increases gonadotropin secretion and testicular testosterone production. This oral medication offers an alternative for men unwilling or unable to use injectable therapies.
medicationGenetic Evaluation and Counseling
Comprehensive genetic testing including karyotype, Y-chromosome microdeletion analysis, and CFTR mutation screening. Genetic counseling helps predict treatment success and offspring risk.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 83 C5830470?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Riera-Escamilla A, Chianese C.ESHRE/ESGE guidelines for genetic testing in male infertility. Hum Reprod Update. 2022.
Neto FT, Bach PV, Najari BB, Li PS, Goldstein M. Genetics of male infertility: a review of the literature. Fertil Steril. 2021.
Liu C, Wang H, Zhang Y, Chen X. Novel biallelic variants in spermatogenic failure patients: clinical and molecular characterization. J Clin Endocrinol Metab. 2023.
Alves MG, Martins AD, Carvalho M, Sousa M. Molecular mechanisms underlying human spermatogenic failure: a meta-analysis of genomic studies. Andrology. 2020.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 83 C5830470. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy