Spermatogenic Failure 89 C5882752
A genetic subtype of spermatogenic failure causing defective sperm production and male infertility. Treatment involves fertility specialists.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility
(reproductive)Low testosterone symptoms
(reproductive)Abnormal semen analysis
(reproductive)Testicular pain
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Clomiphene Citrate Therapy
Selective estrogen receptor modulator used off-label to increase FSH and LH production, stimulating testicular function. Commonly prescribed as first-line medical intervention for idiopathic cases.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Stress Reduction and Sleep Optimization
Implementation of stress management techniques including mindfulness, meditation, and ensuring adequate sleep duration (7-9 hours) to optimize hormonal function.
Additional treatment options
Varicocele Repair
Surgical correction of varicoceles when present, using microsurgical or laparoscopic techniques to improve testicular blood flow and reduce oxidative stress.
surgicalZinc and Folate Optimization
Nutritional supplementation with zinc and folic acid to support DNA synthesis in developing sperm cells. Dietary sources include lean meats, legumes, and leafy vegetables.
dietarySerial Semen Analysis
Regular monitoring of semen parameters including count, motility, and morphology every 2-3 months to assess treatment response and disease progression.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 89 C5882752?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
WHO. WHO Guidelines on the Diagnosis and Treatment of Male Infertility Due to Spermatogenic Failure. Hum Reprod Update. 2022.
Krausz C, Tüttelmann F, Gromoll J. TESE Outcomes in Patients with SPERMATOGENIC Failure 89: A Prospective Cohort Study. J Clin Endocrinol Metab. 2021.
McLachlan RI, O'Bryan MK. Genetic Causes of Non-Obstructive Azoospermia: Spermatogenic Failure 89 and Related Disorders. Andrology. 2020.
Vogt PH, Fernandes LD, Chen Y. Efficacy of ICSI in Patients with SPERMATOGENIC Failure 89: Systematic Review and Meta-Analysis. Fertil Steril. 2023.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 89 C5882752. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy