Spermatogenic Failure X Linked 5 C5829558
A hereditary form of male infertility caused by gene mutations on the X chromosome that interfere with sperm cell formation. Assisted reproductive techniques are often needed for conception.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Male infertility
(reproductive)Low semen volume
(reproductive)Azoospermia
(reproductive)Testicular atrophy
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Micro-TESE (Microscopic Testicular Sperm Extraction)
Microscopic surgical technique to locate and extract sperm from testicular tissue. This is the most effective surgical method for men with non-obstructive azoospermia, allowing identification of discrete foci of sperm production within the testes.
ICSI (Intracytoplasmic Sperm Injection) with IVF
Advanced assisted reproductive technology where a single sperm is directly injected into an egg. Combined with surgical sperm retrieval, this represents the primary path to biological parenthood for men with severe spermatogenic failure.
Additional treatment options
Hormone Stimulation Therapy
Combination therapy using clomiphene citrate or anastrozole to optimize testosterone-to-estradiol ratio, potentially improving spermatogenesis. May be used adjunctively before or between ART cycles.
medicationScrotal Heat Avoidance
Lifestyle modifications to reduce testicular heat exposure, including avoiding hot tubs, saunas, tight underwear, and prolonged sitting. Heat reduction supports optimal sperm production environment.
lifestyleFertility Counseling and Support
Specialized psychological support addressing the emotional impact of infertility diagnosis, treatment stress, and potential family planning concerns. Includes coping strategies and communication techniques for couples.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure X Linked 5 C5829558?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Cioppi F, Riera-Escamilla A. Genetic factors of non-obstructive azoospermia: consequences for clinical management. Hum Reprod Update. 2022.
Jungwirth A, Diemer T, Dohle GR, Kopa Z, Krausz C, Tournaye H. European Association of Urology Guidelines on Male Infertility. Eur Urol. 2021.
Xie C, Wang H, Liu L, Chen Y. Novel mutations in TEX11 gene associated with spermatogenic failure. Andrology. 2020.
Nuti F, Krausz C, Kahraman S. X-linked genetic causes of male infertility: a systematic review. Int J Mol Sci. 2023.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure X Linked 5 C5829558. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy