Spermatogenic Failure Y Linked 1 C4551960
A genetic form of male infertility caused by deletions on the Y chromosome affecting genes critical for sperm production. Severity varies by specific genetic deletion. Genetic testing and fertility counseling are essential.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Oligospermia
(reproductive)Reduced sperm motility
(reproductive)Testicular atrophy
(reproductive)Elevated FSH levels
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Intracytoplasmic Sperm Injection (ICSI) with Microfluidic Sperm Selection
Advanced IVF technique using specialized sperm selection methods to isolate motile, morphologically normal sperm for injection. Particularly relevant for Y-linked microdeletions where sperm may be present in low numbers.
Microsurgical Testicular Sperm Extraction (Micro-TESE)
Microscope-assisted surgical search for focal areas of spermatogenesis within testicular tissue. Higher success rates than conventional TESE for non-obstructive azoospermia associated with Y deletions.
Additional treatment options
Comprehensive Genetic Testing and Counseling
Karyotype analysis and Y chromosome microdeletion testing to define extent of deletion. Counseling addresses inheritance implications including potential male infertility transmission to offspring.
monitoringEmpiric Hormone Stimulation
Off-label use of FSH-containing preparations or SERMs to attempt stimulation of spermatogenesis. Generally has limited efficacy for complete AZF deletions but may be tried in partial deletions.
medicationAntioxidant Supplementation
Coenzyme Q10, vitamin E, selenium, and other antioxidants may improve sperm parameters in some men. Evidence is supportive but not definitive for genetic causes of infertility.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure Y Linked 1 C4551960?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
European Association of Urology. EAU Guidelines on Male Infertility: Y-Chromosome Microdeletions. Eur Urol. 2022.
Krausz C, Casamonti E, Petrović I. Y-Chromosome Microdeletions: A Cornerstone of Male Infertility. Hum Reprod Update. 2023.
Simoni M, Tüttelmann F, Gromoll J. Clinical Consequences of Y-Chromosome Microdeletions: A Systematic Meta-Analysis. Andrology. 2021.
Vogt PH. Molecular Genetics of Human Male Infertility: AZF Region Deletions. In: Nieschlag E, Behre HM, eds. Andrology. Springer; 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy