Stage 4 Chronic Kidney Disease C2317473
Stage 4 chronic kidney disease is severe kidney failure where the organs have lost most filtering function. It primarily affects adults, often from diabetes or high blood pressure. Treatment requires dialysis or kidney transplant, along with careful management of related complications like high blood pressure and anemia.
Key facts at a glance
- ICD-10
- I12.9, I13.0, I13.10
- ICD-11
- BA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Fatigue
(renal)Peripheral edema
(renal)Nausea
(gastrointestinal)Peripheral neuropathy
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Renal Replacement Therapy Planning
Comprehensive preparation for dialysis including vascular access creation and education on hemodialysis or peritoneal dialysis options.
Renal Diet Modification
Protein, potassium, phosphorus, and sodium restriction along with fluid management to reduce kidney burden and prevent complications.
Additional treatment options
CKD Complication Management
Treatment of anemia with ESAs or iron, phosphate control with binders, calcium-vitamin D supplementation, and blood pressure control.
medicationCardiovascular Risk Reduction
Smoking cessation, regular moderate exercise within limitations, weight management, and stress reduction techniques.
lifestyleKidney Transplant Evaluation
Comprehensive evaluation for transplant candidacy including cardiac assessment, cancer screening, and psychosocial evaluation.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Stage 4 Chronic Kidney Disease C2317473?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013;3(1):1-150.
Romagnani P, Almulki L, Bader E, et al. Management of Patients with Stage 4 Chronic Kidney Disease: A Clinical Review. Clin J Am Soc Nephrol. 2021;16(7):1102-1114.
Heerspink HJL, Stefansson BV, Correa-Rotter R, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446.
Zhang J, Chen Y, Wang Q, et al. Cardiovascular Outcomes in Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Nephrol Dial Transplant. 2022;37(5):897-908.
Medication Comparisons
Compare medications used to treat Stage 4 Chronic Kidney Disease C2317473. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy