Subcutaneous Panniculitis Like T Cell Lymphoma C0522624
Subcutaneous panniculitis-like T-cell lymphoma is a rare cancer affecting the fat layer under the skin. It often presents with tender skin nodules and may involve autoimmune-like symptoms. Treatment typically includes chemotherapy.
Key facts at a glance
- ICD-10
- C86.30, C86.31
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hemophagocytic syndrome
Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Subcutaneous nodules
(integumentary)Fever
(integumentary)Weight loss
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Systemic corticosteroids
High-dose corticosteroid therapy as primary anti-inflammatory treatment to suppress the atypical T-cell proliferation and associated inflammatory response in subcutaneous panniculitis-like T-cell lymphoma.
Chemotherapy regimens
Multi-agent chemotherapy protocols including agents such as cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) for advanced or refractory disease cases.
Additional treatment options
Regular imaging and laboratory assessment
Serial CT or PET-CT imaging combined with regular complete blood counts and lactate dehydrogenase monitoring to assess treatment response and detect disease progression.
monitoringLymphedema management
Specialized physical therapy including manual lymphatic drainage and compression garments to address secondary lymphedema that may develop in affected extremities.
physical_therapyPsychosocial support and counseling
Professional psychological support to address the emotional impact of lymphoma diagnosis, treatment side effects, and body image concerns associated with skin manifestations.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Subcutaneous Panniculitis Like T Cell Lymphoma C0522624?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Willemze R, Hodak E, Zinzani PL, et al. Primary cutaneous lymphomas: ESMO-EORTC consensus recommendations. Ann Oncol. 2021;32(10):1233-1247.
Kong YY, Dai B, Kong JC, et al. Subcutaneous panniculitis-like T-cell lymphoma: a clinical update and diagnostic challenges. Br J Dermatol. 2020;183(4):657-665.
Michonneau D, Petrella T, Dalle S, et al. Subcutaneous panniculitis-like T-cell lymphoma: outcomes and prognostic factors in a series of 76 patients. Blood. 2019;134(18):1514-1521.
Miyashiro D, Sanches JA, Miyuki MM, et al. Treatment of subcutaneous panniculitis-like T-cell lymphoma: a systematic review. Crit Rev Oncol Hematol. 2022;172:103625.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy