Syndromic X Linked Intellectual Disability Claes Jensen Type C1845243
A rare genetic disorder causing intellectual disability, unique facial characteristics, and sometimes additional health issues in males. Supportive therapies help manage symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spasticity
(neurologic)Intellectual disability
(neurologic)Hypogonadism
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Early Intervention Developmental Program
Comprehensive early childhood intervention including speech, occupational, and physical therapy services tailored to individual needs. Services typically begin in infancy and continue through school years to maximize developmental potential and functional abilities.
Symptom-Specific Pharmacological Management
Targeted medication approach addressing co-occurring conditions such as anxiety, hyperactivity, mood instability, or seizure activity. Medications are selected based on specific symptom presentation and response.
Additional treatment options
Motor Skills Development Therapy
Specialized physical therapy focused on improving coordination, balance, muscle tone regulation, and gross motor function. Sessions incorporate play-based activities to enhance engagement and motor learning.
physical_therapyStructured Home Environment and Routine
Creation of predictable daily schedules with clear visual supports and consistent expectations. Environmental modifications reduce anxiety and support behavioral regulation and skill acquisition.
lifestyleMultidisciplinary Surveillance Protocol
Regular monitoring by genetics, neurology, cardiology, and developmental pediatrics teams to screen for associated medical complications including cardiac anomalies, seizures, and growth abnormalities.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Syndromic X Linked Intellectual Disability Claes Jensen Type C1845243?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kaufmann L, Rauch A, Winter D. X-linked intellectual disability syndromes: Clinical features and molecular mechanisms. Orphanet J Rare Dis. 2022.
Meyer P, Thompson R, van Balkom I, et al. European guidelines for diagnosis and management of syndromic intellectual disabilities. Eur J Hum Genet. 2021.
Nguyen H, Santos M, Fischer J. Clinical and genetic characterization of families with X-linked intellectual disability: A prospective cohort study. Clin Genet. 2020.
Chen W, Okonkwo M, Lindqvist A. Neurodevelopmental phenotypes in genetic syndromes: A systematic review and meta-analysis. Dev Med Child Neurol. 2023.
Medication Comparisons
Compare medications used to treat Syndromic X Linked Intellectual Disability Claes Jensen Type C1845243. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy