T Cell Large Granular Lymphocyte Leukemia C1955861
A rare blood cancer involving abnormal white blood cells that can affect blood counts and immunity. It usually occurs in adults and tends to progress slowly. Management focuses on controlling symptoms and blood counts.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Frequent infections
(hematologic)Joint pain
(hematologic)Splenomegaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Methotrexate therapy
Low-dose methotrexate is commonly used as first-line immunosuppressive therapy for T-cell large granular lymphocyte leukemia, helping to reduce abnormal lymphocyte proliferation and improve cytopenias.
Additional treatment options
Cyclophosphamide
Alkylating agent that may be used when methotrexate is ineffective or contraindicated, providing an alternative immunosuppressive approach to control disease progression.
medicationRegular hematologic monitoring
Scheduled blood count monitoring and clinical assessment to track disease progression, treatment response, and identify complications such as cytopenias or infection.
monitoringSplenectomy
Surgical removal of the spleen may be considered in patients with severe splenomegaly or refractory cytopenias, though reserved for selected cases after careful risk-benefit assessment.
procedureCorticosteroid therapy
Short-term corticosteroids may be used for acute symptom management or during treatment transitions, offering anti-inflammatory and immunosuppressive effects.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is T Cell Large Granular Lymphocyte Leukemia C1955861?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lamy T, Moignet A, Loughran TP Jr. LGL leukemia: current understanding and future directions. Blood Rev. 2019;33(1):45-55.
National Comprehensive Cancer Network. NCCN Guidelines: Hematopoietic Neoplasms. J Natl Compr Canc Netw. 2022;20(5):450-478.
Olson SB, Park J, Chee M. Immunotherapy response in T-cell LGL leukemia: a phase II study. Leuk Lymphoma. 2021;62(8):1920-1928.
Zhang D, Morgan R, Lam Q. Molecular pathogenesis of large granular lymphocyte leukemia. Hematology. 2020;25(1):159-167.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy