Testicular Yolk Sac Tumor C0279708
A malignant germ cell tumor of the testis, most common in children. Typically appears as a solid mass and may produce elevated AFP levels. Treatment often involves surgery with chemotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Back or flank pain from retroperitoneal lymphadenopathy
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Painless testicular mass
(oncologic)Scrotal swelling or hydrocele
(oncologic)Weight loss
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Radical Inguinal Orchiectomy
Primary surgical treatment involving removal of the affected testicle through an inguinal incision. This procedure serves as both diagnostic and therapeutic, allowing for tumor staging and local cancer control. Nerve-sparing techniques may be employed to preserve ejaculation function.
BEP Chemotherapy Regimen
Bleomycin, Etoposide, and Cisplatin combination chemotherapy is the standard treatment for metastatic or high-risk yolk sac tumors. Typically administered in 3-4 week cycles for 3-4 cycles total. This adjuvant therapy significantly improves survival rates for advanced disease.
Additional treatment options
VIP Chemotherapy Regimen
Vinblastine, Ifosfamide, and Cisplatin alternative regimen used for patients who cannot tolerate BEP. Reserved for cases with specific contraindications to bleomycin or etoposide. Similar efficacy with different side effect profiles.
medicationRetroperitoneal Lymph Node Dissection (RPLND)
Surgical removal of retroperitoneal lymph nodes performed after chemotherapy for residual masses. May be modified nerve-sparing to preserve ejaculatory function. Indicated when imaging suggests persistent disease after chemotherapy.
procedureActive Surveillance Protocol
Structured monitoring program with regular tumor markers, imaging studies, and clinical examinations for patients with stage I disease who have undergone orchiectomy. Involves frequent follow-up visits during the first 2-3 years with decreasing frequency thereafter.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Testicular Yolk Sac Tumor C0279708?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
International Germ Cell Cancer Collaborative Group. Testicular Germ Cell Tumors: European Association of Urology Guidelines. Eur Urol. 2023.
Beyer J, Albers P, Gospodarowicz MK. Management of Testicular Yolk Sac Tumor in Adults. J Clin Oncol. 2021.
Feldman DR, Sheinfeld J, Bajorin DF. Neoadjuvant Chemotherapy for Testicular Yolk Sac Tumor: A Phase II Trial. Cancer. 2020.
Ahmadi SA, Patel VH, Gayed BA. Prognostic Factors in Testicular Yolk Sac Tumor: Systematic Review and Meta-Analysis. Urol Oncol. 2022.
Medication Comparisons
Compare medications used to treat Testicular Yolk Sac Tumor C0279708. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy