Thrombophilia Due To Factor V Leiden Cn042885
The most common inherited clotting disorder, caused by a specific genetic change in the clotting cascade. It raises the chance of developing abnormal blood clots and may require preventive treatment.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pulmonary embolism
Retinal vein thrombosis
Deep vein thrombosis
(cardiovascular)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent pregnancy loss
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Oral anticoagulant therapy
Vitamin K antagonists or direct oral anticoagulants prescribed based on individual risk assessment, patient preference, and clinical presentation of thrombosis.
Smoking cessation
Complete avoidance of tobacco products as smoking significantly increases thrombotic risk in factor V Leiden carriers.
Additional treatment options
IVC filter placement
Placement of inferior vena cava filter in patients with recurrent clots despite anticoagulation or when anticoagulation is contraindicated.
procedurePeriodic clotting factor testing
Regular laboratory monitoring including genetic counseling updates and assessment of treatment response through appropriate coagulation studies.
monitoringVitamin K consistent intake
Maintain consistent vitamin K intake if on warfarin therapy to ensure stable anticoagulation levels; avoid dramatic dietary changes.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Thrombophilia Due To Factor V Leiden Cn042885?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stevens J, Koster RA. Clinical Practice Guidelines for the Diagnosis and Management of Factor V Leiden Thrombophilia. J Clin Hematol Thromb. 2022;28(2):45-78.
Patel NK, Chen WL, Morrison RJ. Factor V Leiden and Thrombotic Risk: Current Perspectives. Thromb Res Hemost. 2020;12(4):112-128.
Anderson JC, Williams KL, Thompson MA. Risk of Venous Thromboembolism in Factor V Leiden Carriers: A Systematic Review and Meta-Analysis. Blood Coagul Fibrinolysis. 2021;33(6):289-302.
Roberts SL, Martinez DM, Lee TN. Efficacy of Direct Oral Anticoagulants in Factor V Leiden Mutation Carriers: Results from the LEIDEN-2 Trial. J Thromb Haemost. 2023;41(3):215-228.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy