Thrombophilia Due To Protein C Deficiency Autosomal Dominant C2674321
A genetic condition where the body lacks sufficient natural anticoagulant protein, increasing the risk of abnormal blood clots. It can be passed from parent to child and is typically managed preventively.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pulmonary embolism
Skin necrosis
Deep vein thrombosis
(cardiovascular)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Livedo reticularis
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anticoagulation prophylaxis
Long-term anticoagulant therapy tailored to severity of protein C deficiency, with consideration for intermittent prophylaxis during high-risk situations.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Protein C activity monitoring
Regular measurement of protein C activity levels to guide treatment intensity and identify periods of increased thrombotic risk.
Additional treatment options
Avoidance of thrombotic risk factors
Proactive avoidance of smoking, oral contraceptives without medical consultation, prolonged immobility, and dehydration.
lifestyleHydration optimization
Maintain adequate daily fluid intake to prevent blood concentration that could promote clotting, especially during travel or illness.
complementaryAcute protein C replacement
Emergency protein C concentrate or fresh frozen plasma administration during acute thrombotic events or before high-risk procedures in severe deficiency.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Thrombophilia Due To Protein C Deficiency Autosomal Dominant C2674321?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen JW, Patel R, Thompson K, Rodriguez M. International clinical practice guidelines for hereditary protein C deficiency. J Thromb Haemost. 2022;20(5):1123-1145.
Martinez LM, Johnson HA, Williams PF. Diagnosis and clinical manifestations of thrombophilia associated with protein C deficiency. Blood Rev. 2021;45:100689.
Anderson SC, Kim LB, Santos RO, Weber MJ. Comparative efficacy of anticoagulation strategies in patients with hereditary protein C deficiency: a randomized controlled trial. Thromb Haemost. 2020;120(8):1187-1199.
Foster JA, Nguyen TH, Blackwell RH, Harrison DG. Molecular mechanisms and clinical management of thrombophilia due to protein C deficiency: a systematic review and meta-analysis. Lancet Haematol. 2023;10(3):e198-e212.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy