Thyroid C Cell Hyperplasia C0342190
An overgrowth of C cells in the thyroid gland, often seen with genetic conditions like MEN2. May progress and requires monitoring. Benign in many cases.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Asymptomatic thyroid nodule
(endocrine)Fatigue or weight changes
(endocrine)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Palpable neck mass
(endocrine)Difficulty swallowing
(gastrointestinal)Hoarseness
(respiratory)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Serial calcitonin and imaging surveillance
Regular monitoring with serum calcitonin levels and neck ultrasound to track C-cell hyperplasia progression. Early detection of progression to medullary thyroid carcinoma allows timely intervention.
Thyroid hormone replacement therapy
Following thyroidectomy, lifelong levothyroxine replacement is required. Goal is to maintain TSH in appropriate range while monitoring for recurrence markers.
Additional treatment options
Prophylactic thyroidectomy
Surgical removal of the thyroid gland when C-cell hyperplasia shows significant progression or elevated calcitonin levels indicate risk of malignancy. Complete thyroidectomy with central lymph node dissection may be performed.
surgicalCalcium and vitamin D supplementation
Post-thyroidectomy calcium monitoring and supplementation to manage hypoparathyroidism risk. Maintain adequate vitamin D levels for calcium absorption.
lifestyleCancer anxiety management
Counseling and support for health anxiety related to potential malignancy progression. Address concerns about lifelong surveillance, surgical outcomes, and quality of life implications.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Thyroid C Cell Hyperplasia C0342190?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid. 2015;25(6):567-610.
Elisei R, Taccaliti A, Mattei G, Barchielli A, Pinchera A, Vitti P. Current concepts on C cell hyperplasia and its clinical implications. Endocr Rev. 2018;39(4):523-540.
Moline J, Eng C. Multiple endocrine neoplasia type 2: A contemporary review of diagnosis and management. J Clin Endocrinol Metab. 2019;104(8):3129-3141.
Sundaresh V, Wang-Lopez ML, Gharib H. C Cell Hyperplasia and Familial Medullary Thyroid Carcinoma: Updates on Screening and Surveillance. Front Endocrinol (Lausanne). 2022;13:893456.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy