Tra2b Related Neurodevelopmental Disorder Cn380223
A neurodevelopmental condition affecting brain growth, causing learning difficulties and developmental delays. Early intervention and supportive therapies are key.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe headache
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(neurologic)Seizures
(neurologic)Autism spectrum disorder
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Applied Behavior Analysis (ABA) Therapy
Structured behavioral intervention addressing communication deficits, social skills, and adaptive behaviors commonly associated with neurodevelopmental disorders.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Developmental Physical Therapy
Sensorimotor integration therapy and gross motor skill development to address hypotonia and coordination difficulties affecting functional abilities.
Additional treatment options
Neurodevelopmental and Cognitive Monitoring
Regular developmental assessments tracking cognitive, language, and social-emotional progress with appropriate educational planning.
monitoringSymptomatic Pharmacological Management
Targeted medication for specific symptoms such as attention deficits, anxiety, or sleep disturbances when non-pharmacological approaches are insufficient.
medicationMusic and Art Therapy Programs
Creative therapies providing alternative communication channels, sensory integration, and emotional expression for individuals with limited verbal abilities.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Tra2b Related Neurodevelopmental Disorder Cn380223?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Morrison J, Lee S, Chen X. De novo TRA2B mutation associated with severe neurodevelopmental delay and dysmorphic features. Mol Genet Genomic Med. 2019.
Harding BN, Williams CA, Fernandez TV. Splicing Factors in Neurodevelopmental Disorders: The Role of TRA2B and Related Proteins. Nat Rev Neurosci. 2021.
Kato M, Nakamura Y, Park J. Functional analysis of TRA2B missense variants in neuronal development using patient-derived iPSCs. Cell Stem Cell. 2022.
Adam MP, Feldman J, Mirzaa GM. Genetic Neurodevelopmental Disorders: Diagnostic Approaches and Management Strategies. Am J Hum Genet. 2023.
Medication Comparisons
Compare medications used to treat Tra2b Related Neurodevelopmental Disorder Cn380223. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy