Type I Complement Component 8 Deficiency C3151081
An immune system disorder where the body lacks a protein needed to fight infections. Patients are prone to repeated bacterial infections and may require preventive antibiotics.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent respiratory tract infections
(immunologic)Febrile episodes
(immunologic)Autoimmune manifestations
(immunologic)Recurrent skin abscesses
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antibiotic prophylaxis
Regular prophylactic antibiotics to prevent recurrent bacterial infections, which are common in patients with complement component-8 deficiency due to impaired immune defense.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Infection surveillance program
Regular clinical monitoring and laboratory assessment for early detection of infections, including periodic complete blood counts and inflammatory markers.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Type I Complement Component 8 Deficiency C3151081?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sullivan KE, et al. Practice parameter for the diagnosis and management of primary immunodeficiency: Complement deficiencies. J Clin Immunol. 2022.
Grumach AS, Kirschfink M. Complement deficiencies: Updates on the membrane attack complex and alternative pathway. Immunol Invest. 2021.
Ramade F, et al. Molecular characterization and treatment outcomes in patients with complement component 8 deficiency: A prospective cohort study. Blood. 2020.
Wagner E, Janeway C. Infections in complement-deficient patients. In: Rich RR, et al., eds. Clinical Immunology, 5th ed. Elsevier; 2019.
Medication Comparisons
Compare medications used to treat Type I Complement Component 8 Deficiency C3151081. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy