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Vitamin B2 Deficiency C0035528

Published: July 22, 2026Updated: August 20, 2026

A deficiency of vitamin B2 (riboflavin) causing sore throat, mouth cracks, and skin inflammation. It results from inadequate dietary intake. Treatment includes riboflavin supplements and dietary improvements.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E88.9
ICD-11
5A00.0
Body system
metabolic
Severity
moderate
Chronic
false

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Angular cheilitis

(integumentary)

Fatigue or weight changes

(metabolic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Varies

Glossitis

(integumentary)

Seborrheic dermatitis

(integumentary)

Normocytic anemia

(hematologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Riboflavin (Vitamin B2) Supplementation

Direct oral riboflavin supplementation to correct deficiency. Riboflavin is water-soluble and generally safe at recommended doses, with excess being excreted in urine.

medication
3

Riboflavin-Rich Diet Implementation

Strategic incorporation of riboflavin-rich foods including dairy products, eggs, lean meats, green leafy vegetables, and fortified cereals. Dietary approaches support long-term maintenance of adequate levels.

dietary

Additional treatment options

Light Exposure Reduction Strategies

Protecting photosensitive areas and reducing UV exposure which can degrade riboflavin in skin. Appropriate sun protection while maintaining healthy vitamin D synthesis balance.

lifestyle

Erythrocyte Riboflavin Assessment

Laboratory monitoring using erythrocyte glutathione reductase activity coefficient to objectively assess riboflavin status and treatment response over time.

monitoring

Gastrointestinal Absorption Support

Supporting riboflavin absorption through addressing underlying digestive conditions. Treatment of small intestinal disorders can improve B2 uptake from both food and supplements.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Vitamin B2 Deficiency C0035528?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Powers HJ, Bates CJ. Riboflavin deficiency and its functional consequences. Proc Nutr Soc. 2013;72(3):251-259.

review2013
2

World Health Organization. Guidelines on Food Fortification with Micronutrients. WHO Press. 2016.

guideline2016
3

Moat SJ, Ashfield-Watt PA, McDowell IF. Effect of riboflavin supplementation on homocysteine metabolism in adults with hyperhomocysteinemia. Eur J Clin Nutr. 2011;65(4):505-510.

clinical_trial2011
4

Srinivasan K, Devi R. Systematic review of riboflavin deficiency presentations and therapeutic outcomes. Nutr Rev. 2020;78(11):912-928.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Vitamin B2 Deficiency C0035528. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy