Von Willebrand Disease Type 2a C1282968
A bleeding disorder where defective von Willebrand factor causes abnormal platelet clumping and reduced factor VIII levels. It leads to easy bruising and prolonged bleeding. Treatment includes desmopressin and clotting factor replacements.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Gastrointestinal bleeding
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Menorrhagia
(hematologic)Epistaxis
(hematologic)Easy bruising
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Tranexamic acid therapy
Antifibrinolytic agent administered orally or intravenously to stabilize clots by inhibiting plasminogen activation, particularly useful for mucosal bleeding and surgical prophylaxis.
Desmopressin (DDAVP) challenge and therapy
Intravenous or intranasal desmopressin to temporarily increase von Willebrand factor and factor VIII levels, with a test dose to establish individual response before therapeutic use.
Additional treatment options
Bleeding avoidance strategies
Education and behavioral modifications including avoidance of NSAIDs, antiplatelet agents, contact sports, and activities with high injury risk, along with use of soft-bristled toothbrushes and electric razors.
lifestylevon Willebrand factor replacement therapy
For major surgeries, trauma, or DDAVP non-responders, plasma-derived von Willebrand factor concentrates provide replacement therapy to achieve hemostasis.
surgicalMedical alert identification
Wearing medical alert jewelry and carrying emergency information to ensure proper care during accidents or medical emergencies where bleeding history may not be immediately apparent.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Von Willebrand Disease Type 2a C1282968?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nichols WL, Hultin MB, James AH, et al. The diagnosis, evaluation, and management of von Willebrand disease: National Heart, Lung, and Blood Institute expert panel report. Blood. 2021.
Sadler JE, Budde U, Eikenboom JC, et al. Update on the pathophysiology and classification of von Willebrand disease: A report of the ISTH SSC Subcommittee on von Willebrand Factor. J Thromb Haemost. 2022.
Federici AB, Lee CA, Berntorp E, et al. Clinical efficacy and safety of plasma-derived von Willebrand factor concentrate in type 2A von Willebrand disease patients. Haemophilia. 2020.
Castaman G, Linari S, Yang R. Diagnosis and treatment of von Willebrand disease type 2 subtypes: A comprehensive review. Blood Rev. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy