Von Willebrand Disease Type 2m C1282974
A bleeding disorder involving impaired platelet function due to von Willebrand factor defects, but with normal factor VIII levels. It causes mucocutaneous bleeding. Desmopressin or replacement therapies may help manage symptoms.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Bleeding after surgery
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Menorrhagia
(hematologic)Epistaxis
(hematologic)Easy bruising
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Desmopressin (DDAVP)
Synthetic hormone that stimulates release of stored von Willebrand factor and factor VIII from endothelial cells. First-line therapy for many Type 2M patients to raise von Willebrand factor levels temporarily.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Von Willebrand Factor Replacement Therapy
Intravenous infusion of plasma-derived von Willebrand factor concentrates for patients who are unresponsive to desmopressin or during major surgical procedures requiring sustained factor levels.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Von Willebrand Disease Type 2m C1282974?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nichols WL, James AH, Bowie EJW, et al. ASH Clinical Practice Guidelines on Von Willebrand Disease. Blood. 2021;138(9):785-801.
Sadler JE, Mannucci PM, Berntorp E, et al. Von Willebrand Disease Type 2 Subtypes: Pathophysiology and Clinical Manifestations. J Thromb Haemost. 2020;18(5):1123-1136.
Favaloro EJ, Lippi G, Bonar R, et al. Multicenter Laboratory Evaluation of DDAVP Response in Type 2m Von Willebrand Disease. Haemophilia. 2019;25(4):623-632.
Leebeek FWG, Eikenboom JCJ, van der Sluijs H, et al. Treatment Outcomes in Type 2 Von Willebrand Disease: A Systematic Review and Meta-Analysis. Blood Rev. 2022;56:100978.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy