Wdr5 Related Neurodevelopmental Disorder Cn380224
A genetic disorder affecting brain development, causing developmental delays and intellectual disability. Affected individuals may also have distinctive facial features. Treatment includes developmental therapies and support.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Developmental delay
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(neurologic)Facial dysmorphism
(neurologic)Microcephaly
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Early Developmental Intervention
Intensive early intervention services including physical, occupational, and speech therapy to maximize developmental potential and functional independence in children with WDR5-related disorder.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Seizure Management
Anticonvulsant therapy for individuals presenting with epilepsy, selected based on seizure type and individual tolerability profile.
Additional treatment options
Neuropsychological Support
Comprehensive cognitive and behavioral assessment with targeted interventions for intellectual disability, attention difficulties, and behavioral challenges common in this population.
psychologicalStructured Daily Routines
Implementation of consistent, predictable daily schedules and environmental modifications to support learning, reduce anxiety, and maximize functional abilities.
lifestyleGrowth and Endocrine Monitoring
Regular assessment of growth parameters, feeding adequacy, and endocrine function given reported associations with failure to thrive and growth hormone deficiency.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Wdr5 Related Neurodevelopmental Disorder Cn380224?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson LK, Williams PL. Practice guidelines for genetic evaluation of neurodevelopmental disorders. Genet Med. 2022.
Chen X, Martinez-Hernandez A, Thompson BA. WDR5 function in epigenetic regulation and neurodevelopmental processes. Nat Rev Neurosci. 2021.
Patel RR, Okonkwo C, Kim HJ, Garcia BA. Clinical characterization of WDR5-associated neurodevelopmental syndrome: a case series. Am J Hum Genet. 2023.
Nguyen HT, Fernandez SC, Robinson D, Lee KW. Genetic determinants of neurodevelopmental disorders: a systematic review and meta-analysis. Ann Neurol. 2020.
Medication Comparisons
Compare medications used to treat Wdr5 Related Neurodevelopmental Disorder Cn380224. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy