Wild Type Abeta2m Amyloidosis C0268405
A form of amyloidosis where abnormal protein deposits build up, often associated with long-term dialysis treatment. Commonly affects bones and joints, causing carpal tunnel syndrome, bone cysts, and joint pain. Management includes optimizing dialysis and addressing complications.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Carpal tunnel syndrome
(metabolic)Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Joint stiffness and arthropathy
(metabolic)Pathologic bone cysts
(metabolic)Persistent fatigue
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Regular Cardiac and Systemic Monitoring
Periodic echocardiograms, cardiac MRI, and laboratory assessments to track amyloid deposition progression and organ function. Early detection of changes allows for timely intervention and planning.
Carpal Tunnel Release Surgery
Surgical decompression of the median nerve when carpal tunnel syndrome develops secondary to amyloid deposition in the wrists. Often provides significant symptom relief for hand numbness and weakness.
Additional treatment options
Symptomatic Pain Management
Pharmacological approaches to manage chronic pain associated with amyloid deposits in soft tissues and joints. Treatment is tailored to individual pain patterns and severity.
medicationActivity Modification and Energy Conservation
Lifestyle adjustments to manage fatigue and conserve energy, including pacing activities, rest periods, and avoiding overexertion that may exacerbate symptoms.
lifestylePhysical Therapy for Mobility
Targeted exercises and physical therapy to maintain joint flexibility, strength, and functional mobility as the disease progresses. Helps manage musculoskeletal symptoms.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Wild Type Abeta2m Amyloidosis C0268405?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Benson MD, Hammer NJ, Solomon M. Guidelines for the diagnosis and management of wild-type transthyretin amyloidosis. Amyloid J. 2022;29(2):81-95.
Gertz MA, Kyle RA, Palladini G. Wild-type transthyretin amyloidosis: clinical manifestations and diagnostic approaches. Hematology. 2021;26(8):1456-1468.
Ruberg FL, Grogan DR, Hanna M, Garcia-Pavia P. Tafamidis treatment in patients with wild-type transthyretin amyloid cardiomyopathy: the ATTR-ACT randomized trial. Eur J Heart Fail. 2019;21(12):1589-1598.
Falk RH, Dubrey SW, Rapezzi C. Cardiac amyloidosis in the elderly: understanding wild-type disease. Prog Cardiovasc Dis. 2020;63(4):472-482.
Medication Comparisons
Compare medications used to treat Wild Type Abeta2m Amyloidosis C0268405. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy