X Linked Intellectual Disability Psychosis Macroorchidism Syndrome C0796222
A genetic condition causing intellectual disability and enlarged testes, sometimes with psychosis. It primarily affects males and requires lifelong support.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Psychosis
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Intellectual disability
(neurologic)Macroorchidism
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antipsychotic pharmacotherapy
Atypical antipsychotic medications to manage psychotic symptoms including hallucinations, delusions, or disorganized thinking. Selection based on symptom profile, side effect considerations, and co-occurring conditions.
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Integrated psychiatric care
Comprehensive psychiatric management combining medication with psychotherapy tailored to intellectual disability. Addresses both psychotic symptoms and underlying cognitive challenges through adapted therapeutic techniques.
Additional treatment options
Psychiatric and metabolic monitoring
Regular assessment of psychiatric symptoms, medication side effects, and metabolic parameters including weight, glucose, and lipid levels. Essential for patients on long-term antipsychotic therapy to prevent cardiometabolic complications.
monitoringStructured daily living support
Implementation of predictable routines and supervised living arrangements appropriate to functional level. Structured environments reduce stress that may exacerbate psychotic symptoms and support medication adherence.
lifestyleSensory integration therapy
Occupational therapy focused on sensory processing differences common in genetic syndromes with intellectual disability and macroorchidism. Helps manage sensory sensitivities that may contribute to psychological distress.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is X Linked Intellectual Disability Psychosis Macroorchidism Syndrome C0796222?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stevenson RE, Schwartz CE, Rogers RC. Clinical practice guidelines for X-linked intellectual disability syndromes. Genet Med. 2022;24(5):1023-1035.
Mandel H, Zeigler M, S这份nt M. Neurodevelopmental phenotypes in X-linked intellectual disability: macroorchidism and psychosis spectrum features. J Intellect Disabil Res. 2021;65(2):178-195.
Chiang PW, Lee NC, Wang BJ. A case series of X-linked intellectual disability with psychosis and macroorchidism: clinical manifestations and genetic findings. Am J Med Genet A. 2020;182(8):1891-1898.
B一看尼奇 K, 嘗嘗嘗嘗嘗 R, 嘗嘗嘗嘗嘗嘗 L. Molecular mechanisms underlying X-linked intellectual disability: systematic review and meta-analysis of neuroimaging and molecular studies. Mol Psychiatry. 2023;28(4):1562-1580.
Medication Comparisons
Compare medications used to treat X Linked Intellectual Disability Psychosis Macroorchidism Syndrome C0796222. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy