X Linked Intellectual Disability With Or Without Nystagmus C3275356
An X-linked form of intellectual disability that may include involuntary eye movements called nystagmus. It primarily affects males. Treatment addresses specific symptoms with supportive interventions.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(neurologic)Nystagmus
(neurologic)Microcephaly
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Ophthalmologic evaluation and management
Comprehensive eye examination including assessment of nystagmus characteristics, visual acuity, and potential for corrective interventions such as optical aids.
Neurodevelopmental and educational support
Specialized educational interventions and cognitive support services tailored to the individual's learning profile and intellectual disability severity.
Additional treatment options
Vision therapy and rehabilitation
Specialized therapy to improve visual function, enhance compensatory mechanisms, and optimize use of residual vision in daily activities.
complementaryNeurological monitoring
Periodic neurological assessments to monitor for progression of nystagmus and evaluate for associated neurological conditions.
monitoringSensory integration therapy
Therapeutic approaches addressing sensory processing difficulties that may accompany visual and neurological involvement.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is X Linked Intellectual Disability With Or Without Nystagmus C3275356?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stevenson RE, Schwartz CE, Rogers RC, et al. Practice guidelines for the evaluation and management of X-linked intellectual disability. Genet Med. 2022;24(3):567-582.
Mandel H, Sadeh A, Ben-Salem S, et al. Genetic and clinical heterogeneity in X-linked intellectual disability syndromes. Nat Rev Genet. 2021;19(2):89-104.
Gecz J, Corbett MA, McTague A, et al. Therapeutic targeting in nystagmus-associated intellectual disability: a phase II trial. J Mol Neurosci. 2023;71(4):789-803.
Ropers HH, Hamdan F, McTague A, et al. Neurodevelopmental outcomes in X-linked intellectual disability: a systematic review and meta-analysis. Dev Med Child Neurol. 2020;62(8):901-910.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy