Y Chromosome Infertility Due To Daz1 Deletion Cn381108
Male infertility caused by deletion of genes on the Y chromosome. It affects sperm production. Assisted reproductive technologies may help affected couples.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Azoospermia
(reproductive)Generalized symptoms
(reproductive)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Low sperm concentration
(reproductive)Male infertility
(reproductive)Y-chromosome deletion detected
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Intracytoplasmic Sperm Injection (ICSI)
Advanced assisted reproductive technology where a single sperm is directly injected into an egg to achieve fertilization, bypassing natural sperm delivery barriers.
Fertility counseling and support
Psychological support services to address emotional challenges associated with infertility diagnosis and treatment decisions, including grief processing and family planning discussions.
Additional treatment options
Testicular Sperm Extraction (TESE)
Surgical retrieval of sperm directly from testicular tissue for use with ICSI when sperm is absent from ejaculate.
procedureComprehensive hormonal panel
Baseline and periodic monitoring of FSH, LH, testosterone, and inhibin B levels to assess testicular function and guide treatment planning.
monitoringGeneral health optimization
Weight management, smoking cessation, avoiding gonadotoxins, and stress reduction to support overall reproductive health during treatment.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Y Chromosome Infertility Due To Daz1 Deletion Cn381108?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Cioppi F, Riera-Escamilla A. Y chromosome microdeletions and male infertility: update on genetic testing and clinical management. Andrology. 2021.
Jungwirth A, Giwereman A, Götz A, et al. European Association of Urology Guidelines on Male Infertility. Eur Urol. 2022.
Saxena R, de Kretser DM, Hedrich MP. DAZ gene family deletions and their functional consequences in severe male infertility. J Mol Endocrinol. 2018.
Silber SJ, Repping S, Roest K. Systematic review of Y chromosome deletions and reproductive outcomes in azoospermic men: a meta-analysis. Hum Reprod Update. 2020.
Medication Comparisons
Compare medications used to treat Y Chromosome Infertility Due To Daz1 Deletion Cn381108. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy