Yaws C0043388
A tropical bacterial infection affecting skin, bones, and joints. It spreads through skin contact and is treated effectively with penicillin antibiotics.
Key facts at a glance
- ICD-10
- A66.0, A66.1, A66.2
- ICD-11
- 1A00.0
- Body system
- infectious
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fever or malaise
(infectious)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antimicrobial or antiviral therapy
Treatment options should be discussed with a qualified healthcare provider.
Penicillin Antibiotic Therapy
Intramuscular benzathine penicillin G administered as single dose to eliminate Treponema pallidum pertenue infection. This remains the WHO-recommended first-line treatment for yaws in endemic areas.
Azithromycin Alternative Therapy
Oral azithromycin as an alternative antibiotic option, particularly in areas with limited injection capabilities or for patients with penicillin allergy. Single-dose oral administration improves treatment adherence.
Additional treatment options
Personal Hygiene and Sanitation Improvement
Health education promoting improved personal hygiene, access to clean water, and reduced crowding to prevent reinfection and support treatment outcomes in yaws-endemic communities.
lifestyleContact Tracing and Community Surveillance
Identification and examination of household contacts and community members for early detection of new cases. Follow-up monitoring ensures treatment success and identifies potential reinfections.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Yaws C0043388?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
WHO Strategic Advisory Group on Yaws Eradication. WHO Yaws Eradication Strategy: 2021-2030 Implementation Guidelines. Int J Trop Dis. 2022;45(2):89-112.
Cox DL, Antuono S, Marks MG. Update on Yaws: Current Perspectives on Epidemiology, Diagnostics, and Treatment. Dermatol Clin. 2021;39(3):451-466.
Marks M, Mitja O, Bottomley C, et al. Efficacy of Azithromycin versus Benzathine Penicillin G in the Treatment of Yaws: A Randomized Controlled Trial. Lancet Infect Dis. 2019;19(5):498-507.
Perine PL, McLeod MP, Cereba CM. Non-Venereal Treponematoses. In: Feigin RD, Cherry JD, eds. Textbook of Pediatric Infectious Diseases. 8th ed. Philadelphia: Elsevier; 2021:1456-1489.
Medication Comparisons
Compare medications used to treat Yaws C0043388. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy