Zygomycosis C0043541
A rare but serious fungal infection that attacks the sinuses, lungs, and skin, mainly in people with weakened immune systems. Requires prompt antifungal treatment and sometimes surgery to stop its spread.
Key facts at a glance
- ICD-10
- B46.9
- ICD-11
- 1A00.0
- Body system
- infectious
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever or malaise
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Sinus pain
Orbital cellulitis
Cutaneous necrotic ulcer
Fever
(head and neck)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antifungal therapy with amphotericin B
Intravenous antifungal therapy using amphotericin B as the primary treatment for invasive zygomycosis, working to eliminate the fungal infection systemically.
Antimicrobial or antiviral therapy
Requires immediate emergency medical intervention. Do not delay treatment.
Surgical debridement
Surgical removal of infected and necrotic tissue to reduce fungal burden and improve penetration of antifungal medications.
Additional treatment options
Posaconazole therapy
Secondary antifungal option using posaconazole for salvage therapy or maintenance treatment in patients who cannot tolerate first-line agents.
medicationSerial imaging and laboratory monitoring
Regular monitoring with CT/MRI imaging and inflammatory markers to assess treatment response and detect disease progression.
monitoringHyperbaric oxygen therapy
Adjunctive treatment delivering high concentrations of oxygen to improve tissue healing and create an environment less favorable for fungal growth.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Zygomycosis C0043541?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Cornely OA, Alastruey-Izquierdo A, Arenz D, et al. ESCMID and ECMM joint guidelines on mucormycosis. Clin Microbiol Infect. 2019;25(Suppl 1):1-28.
Spellberg B, Edwards J Jr, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev. 2005;18(3):556-569.
Katragkou A, Tsakalos G, Roilides E. Amphotericin B formulations and liposomal amphotericin B in mucormycosis: a meta-analysis of efficacy and safety. Antimicrob Agents Chemother. 2021;65(8):e0045821.
Prakash H, Chakrabarti A. Global epidemiology of mucormycosis. J Fungi (Basel). 2019;5(1):26.
Medication Comparisons
Compare medications used to treat Zygomycosis C0043541. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy