Once-weekly semaglutide in obesity
Wilding JPH, Batterham RL, Calanna S
New England Journal of Medicine · 2021
This randomized controlled trial evaluates the intervention under study in relation to the primary clinical outcome. Includes 1,961 participants. Evidence level: Ia.
循证研究：司美格鲁肽2.4mg减重研究
Key facts at a glance
- DOI
- 10.1056/NEJMoa2021976
- PMID
- 33881616
- Journal
- New England Journal of Medicine
- Year
- 2021
- Study type
- rct
- Evidence level
- Ia
- Sample size
- 1961
- Intervention
- Semaglutide 2.4mg/周 vs 安慰剂
- Primary outcome
- 体重变化百分比
- Open access
- false
Study Overview
This randomized controlled trial enrolled 1,961 participants and examined the primary clinical outcome.
Key Findings
Results regarding the primary clinical outcome are presented.
Clinical Conclusions
See original publication for detailed findings. Evidence level: Ia.
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Medically reviewed by WellAlly Editorial Team Last reviewed October 18, 2026. · Read our editorial policy