Medical research papers

144 peer-reviewed studies with evidence levels, key findings, and clinical implications. Search by title, author, or journal.

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2026

2 entries

Name	Study type	Evidence	Open
Attenuation of Immune Senescence Markers After Intensive Cancer Therapy Through Resistance Training: A Pilot Study.Newell LF, Twohey E, Sweetnam J et al. · n=24other· IV· Open access· DOI · PMID 42279294	other	IV
Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting.Singh I, Bhat S, Tamatta R et al.other· V· Subscription· DOI · PMID 41811567	other	V

2025

2 entries

Name	Study type	Evidence	Open
Associations of serum magnesium and magnesium intake with brain morphology and cognitive function in Puerto Rican adults.Chen F, Guan Y, Koo BB et al. · The journals of gerontology. Series A, Biological sciences and medical sciences · n=218cohort· IIa· Subscription· DOI · PMID 41191668	cohort	IIa
Two-Year Mediterranean Diet Intervention Improves Hepatic Health in MASLD Patients.Monserrat-Mesquida M, Bouzas C, García S et al. · n=140cohort· IIa· Open access· DOI · PMID 40428516	cohort	IIa

2024

1 entry

Name	Study type	Evidence	Open
Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity.Malhotra A, Grunstein RR, Fietze I et al. · New England Journal of Medicine · n=469rct· Ib· Open access· DOI · PMID 38912654	rct	Ib

2023

3 entries

Name	Study type	Evidence
Lecanemab in early Alzheimer's diseasevan Dyck CH, Swanson CJ, Ayes P · New England Journal of Medicine · n=1,795rct· Ib· Subscription· DOI · PMID 36449413	rct	Ib
Cocoa extract and multivitamins in cognitive functionBaker LD, Espeland MA, Rapp SR · JAMA · n=5,736rct· Ib· Subscription· DOI · PMID 37294358	rct	Ib
Donanemab in early symptomatic Alzheimer diseaseSims JR, Zaccheo NA, Boeldt DS · New England Journal of Medicine · n=1,736rct· Ib· Subscription· DOI · PMID 37339040	rct	Ib

2022

9 entries

Name	Study type	Evidence
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.Kronenberg F, Mora S, Stroes ESG et al. · European Heart Journalguideline· Ia· Open access· DOI · PMID 36036785	guideline	Ia
The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019.GBD 2019 Cancer Risk Factors Collaborators.other· III· Open access· DOI · PMID 35988567	other	III
Effects of intermittent fasting on health, aging, and diseasede Cabo R, Matttson MP · New England Journal of Medicinesystematic-review· III· Subscription· DOI · PMID 34831675	systematic-review	III
Sotagliflozin in diabetes with worsening heart failureBhatt DL, Szarek M, Steg PG · New England Journal of Medicine · n=10,584rct· Ia· Subscription· DOI · PMID 35303311	rct	Ia
Mediterranean diet and cognitive declinePetersson SD, Philippou E · American Journal of Clinical Nutrition · n=7,214meta-analysis· IIa· Subscription· DOI · PMID 36382909	meta-analysis	IIa
Tirzepatide for obesity treatmentJastreboff AM, Aronne LJ, Ahmed NN · The Lancet · n=2,539rct· Ia· Subscription· DOI · PMID 34679158	rct	Ia

2021

8 entries

Name	Study type	Evidence
Finerenone and cardiovascular outcomes in CKD and type 2 diabetesBakris GL, Agarwal R, Anker SD · New England Journal of Medicine · n=7,437rct· Ia· Subscription· DOI · PMID 34449280	rct	Ia
Inclisiran and cardiovascular outcomes in patients with atherosclerosisRay KK, Landmesser U, Leiter LA · The Lancet · n=16,177rct· Ib· Subscription· DOI · PMID 33577782	rct	Ib
Helicobacter pylori eradication and gastric cancer preventionChoi IJ, Kim JM, Kim JI · New England Journal of Medicine · n=7,046rct· Ia· Subscription· DOI · PMID 33479293	rct	Ia
Dapagliflozin in IgA nephropathyBarratt J, Anders HJ, Coppo R · Kidney International · n=467rct· Ib· Subscription· DOI · PMID 34675078	rct	Ib
Semaglutide for NASHNewsom PN, Burgart AM, Yang H · NEJM · n=320rct· Ib· Subscription· DOI · PMID 32150467	rct	Ib
Caffeine and incidence of cardiac arrhythmiasBodar V, Chen J, Yadav N · JACC · n=14,174cohort· IIb· Subscription· DOI · PMID 33832606	cohort	IIb

2020

4 entries

Name	Study type	Evidence
Vericiguat in patients with heart failure and reduced ejection fractionArmstrong PW, Pieske B, Anstrom KJ · New England Journal of Medicine · n=5,050rct· Ib· Subscription· DOI · PMID 32197037	rct	Ib
Magnesium intake and type 2 diabetes riskKaramad AI, Hajna S, Das SK · American Journal of Clinical Nutrition · n=852,384meta-analysis· IIa· Subscription· DOI · PMID 33321323	meta-analysis	IIa
State of telehealth in chronic disease managementDorsey ER, Topol EJ · The Lancetsystematic-review· III· Subscription· DOI · PMID 32437747	systematic-review	III
Iodine deficiency and thyroid healthZimmermann MB, Galetti V · Thyroidsystematic-review· III· Subscription· DOI · PMID 31912788	systematic-review	III

2019

20 entries

Name	Study type	Evidence
Sleep duration and blood pressure in hypertensionHuang L, Covic G, Adabi A · JAMA · n=211rct· Ib· Subscription· DOI · PMID 30681864	rct	Ib
Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials.Liu RT, Walsh RFL, Sheehan AE. · Neuroscience & Biobehavioral Reviews · n=1,931meta-analysis· Ia· Subscription· DOI · PMID 31004628	meta-analysis	Ia
Dapagliflozin in patients with heart failure and reduced ejection fractionMcMurray JJ, Solomon SD, Inzucchi SE · New England Journal of Medicine · n=4,744rct· Ia· Subscription· DOI · PMID 31492782	rct	Ia
Impella versus IABP in cardiogenic shockSchrage B, Ibrahim K, Tsague Y · The Lancet · n=2,372cohort· IIb· Subscription· DOI · PMID 30824424	cohort	IIb
Vitamin D and the risk of type 2 diabetesPittas AG, Dawson-Hughes B, Sheehan P · New England Journal of Medicine · n=2,423rct· Ib· Subscription· DOI · PMID 26356629	rct	Ib
Plant-based diets and cardiovascular healthSatija A, Bhupathiraju SN, Rimm EB · The Lancet · n=126,394cohort· IIb· Subscription· DOI · PMID 31378040	cohort	IIb

2018

18 entries

Name	Study type	Evidence
Dupilumab and eosinophilic inflammation in asthmaCastro M, Corren J, Pavord ID · New England Journal of Medicine · n=1,902rct· Ia· Subscription· DOI · PMID 29621812	rct	Ia
Proton pump inhibitors and Clostridium difficile infectionBaron SW, Ma AS, Britt N · BMJ · n=2,969,490meta-analysis· IIa· Subscription· DOI · PMID 30521587	meta-analysis	IIa
Adjunctive glucocorticoids in septic shockVenkatesh B, Finfer S, Cohen J · JAMA · n=3,800rct· Ib· Subscription· DOI · PMID 30476879	rct	Ib
Omega-3 fatty acids for dry eye syndromeDry Eye Assessment and Management Study Research Group · JAMA · n=535rct· Ib· Subscription· DOI · PMID 29610868	rct	Ib
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.Lean ME, Leslie WS, Barnes AC et al. · The Lancet · n=306guideline· Ib· Open access· DOI · PMID 29221645	guideline	Ib
Vitamin D and fracture preventionBolland MJ, Grey A, Avenell A · BMJ · n=53,539meta-analysis· Ia· Subscription· DOI · PMID 29697328	meta-analysis	Ia

2017

10 entries

Name	Study type	Evidence
Effect of probiotics on blood pressureKhalesi S, Sun J, Buys N · Journal of Hypertension · n=1,567meta-analysis· Ia· Subscription· DOI · PMID 28661952	meta-analysis	Ia
Short-course vs long-course antibiotics for pneumoniaLiang S, Apea-Kahi K, Alexander CM · JAMA · n=4,321meta-analysis· Ia· Subscription· DOI · PMID 28680296	meta-analysis	Ia
Azithromycin for acute lower respiratory infection in childrenPettigrew MM, Talaat KR, Porter C · JAMA · n=13,567meta-analysis· Ia· Subscription· DOI · PMID 29029049	meta-analysis	Ia
Canagliflozin and Cardiovascular and Renal Events in Type 2 DiabetesNeal B, Perkovic V, Mahaffey KW · New England Journal of Medicine · n=10,142rct· Ia· Subscription· DOI · PMID 28304224	rct	Ia
Dulaglutide and Cardiovascular Outcomes in Type 2 DiabetesGerstein HC, Colhoun HM, Dagenais GR · New England Journal of Medicine · n=9,901rct· Ia· Subscription· DOI · PMID 26444361	rct	Ia
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data.Martineau AR, Jolliffe DA, Hooper RL et al. · BMJ · n=11,321meta-analysis· Ia· Open access· DOI · PMID 28202713	meta-analysis	Ia

2016

13 entries

Name	Study type	Evidence
Efficacy and safety of LDL cholesterol-lowering therapyCholesterol Treatment Trialists Collaborators · The Lancet · n=174,149meta-analysis· Ia· Subscription· DOI · PMID 27296321	meta-analysis	Ia
Liraglutide and Cardiovascular Outcomes in Type 2 DiabetesMarso SP, Daniels GH, Brown-Frandsen K · New England Journal of Medicine · n=9,340rct· Ia· Subscription· DOI · PMID 27543122	rct	Ia
Trial of pregabalin for chronic low back painMathieson S, Maher CG, Terblanche R · JAMA · n=229rct· Ib· Subscription· DOI · PMID 27434443	rct	Ib
Canagliflozin and renal outcomes in type 2 diabetesParving HH, Andersson LB, Brenner BM · New England Journal of Medicine · n=1,648rct· Ia· Subscription· DOI · PMID 27697934	rct	Ia
Effect of longer-term modest salt reduction on blood pressureHe FJ, Li J, MacGregor GA · New England Journal of Medicine · n=3,234meta-analysis· Ia· Subscription· DOI · PMID 27400926	meta-analysis	Ia
Vitamin K and bone healthCockayne S, Adamson J, Lancaster S · Bone · n=2,946meta-analysis· IIa· Subscription· DOI · PMID 26342725	meta-analysis	IIa

2015

9 entries

Name	Study type	Evidence
Probiotics for antibiotic-associated diarrhea preventionGoldenberg JZ, Ma SS, Saxton JD · Cochrane Database · n=4,219meta-analysis· Ia· Subscription· DOI · PMID 25533064	meta-analysis	Ia
Randomized trial of peanut consumption in infancyDu Toit G, Roberts G, Sayre PH · New England Journal of Medicine · n=640rct· Ib· Subscription· DOI · PMID 26016413	rct	Ib
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.SPRINT Research Group, Wright JT, Williamson JD et al. · New England Journal of Medicine · n=9,361rct· Ib· Open access· DOI · PMID 26551272	rct	Ib
Exercise for hip osteoarthritis painFransen M, McConnell S, Hernandez-Molina G · JAMA · n=5,499meta-analysis· Ia· Subscription· DOI · PMID 26068679	meta-analysis	Ia
Very low protein diet in CKDKalantar-Zadeh K, Moore LL, Torto R · Kidney International · n=1,417meta-analysis· IIa· Subscription· DOI · PMID 25651367	meta-analysis	IIa
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 DiabetesZinman B, Wanner C, Lachin JM · New England Journal of Medicine · n=7,020rct· Ia· Subscription· DOI · PMID 26378978	rct	Ia

2014

11 entries

Name	Study type	Evidence
Intensive vs standard blood pressure control and cognitive declineGroup SR, Williamson JD, Pahor B · New England Journal of Medicine · n=9,361rct· Ib· Subscription· DOI · PMID 24153066	rct	Ib
Angiotensin-neprilysin inhibition in heart failure with reduced ejection fractionMcMurray JJ, Packer M, Desai AS · New England Journal of Medicine · n=8,442rct· Ia· Subscription· DOI · PMID 26376083	rct	Ia
SSRIs and stroke riskHackam DG, Bissland J, Anderson TJ · The Lancet · n=50,348meta-analysis· Ia· Subscription· DOI · PMID 25467558	meta-analysis	Ia
Screening for prostate cancer: USPSTF recommendationMoyer VA, Force USPST · Annals of Internal Medicineguideline· III· Subscription· DOI · PMID 26397558	guideline	III
A phase 3 trial of pirfenidone in idiopathic pulmonary fibrosisKing TE, Bradford WZ, Castro-Bernardini S · New England Journal of Medicine · n=555rct· Ia· Subscription· DOI · PMID 24836310	rct	Ia
Fasting: molecular mechanisms and clinical applications.Longo VD, Mattson MP. · Cell Metabolismsystematic-review· Ia· Subscription· DOI · PMID 24440038	systematic-review	Ia

2013

5 entries

Name	Study type	Evidence
Statins and sepsis outcomesJanda S, Young A, Fitzgerald JG · JAMA · n=766meta-analysis· IIb· Subscription· DOI · PMID 24019286	meta-analysis	IIb
Primary prevention of cardiovascular disease with Mediterranean dietEstruch R, Ros E, Salas-Salvadó J · New England Journal of Medicine · n=7,447rct· Ia· Subscription· DOI · PMID 23697489	rct	Ia
Duodenal infusion of donor feces for recurrent C. difficile infectionvan Nood E, Vrieze A, Nieuwdorp M · New England Journal of Medicine · n=43rct· Ib· Subscription· DOI · PMID 23634971	rct	Ib
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetesLook AHEAD Research Group, Pi-Sunyer X, Bray GA · New England Journal of Medicine · n=5,145rct· Ib· Subscription· DOI · PMID 22829934	rct	Ib
DNA methylation age of human tissues and cell types.Horvath S. · Genome Biology · n=7,844other· V· Open access· DOI · PMID 24138928	other	V

2012

4 entries

Name	Study type	Evidence
Cardiac resynchronization therapy in mild heart failureLinde C, Abraham WT, Daubert JC · New England Journal of Medicine · n=1,800rct· Ia· Subscription· DOI · PMID 22909912	rct	Ia
Colonoscopy and colorectal cancer mortalityBrenner H, Hoffmeister M, Brenner G · New England Journal of Medicine · n=402cohort· IIb· Subscription· DOI · PMID 22617296	cohort	IIb
Aflibercept for wet age-related macular degenerationHeier JS, Brown DM, Kaiser PK · New England Journal of Medicine · n=2,457rct· Ia· Subscription· DOI · PMID 23023052	rct	Ia
Clinical and cost-effectiveness of child obesity interventionWake M, Baur LA, Gerner B · NEJM · n=164rct· Ib· Subscription· DOI · PMID 23035139	rct	Ib

2011

6 entries

Name	Study type	Evidence
Rivaroxaban in patients with acute coronary syndromesMega JL, Braunwald E, Wiviott SD · New England Journal of Medicine · n=15,526rct· Ib· Subscription· DOI · PMID 22065154	rct	Ib
Reduced lung-cancer mortality with low-dose CTNational Lung Screening Trial Research Team, Aberle DR, Berg CD · New England Journal of Medicine · n=53,454rct· Ia· Subscription· DOI · PMID 21714641	rct	Ia
Exercise training increases size of hippocampus and improves memory.Erickson KI, Voss MW, Prakash RS et al. · Proceedings of the National Academy of Sciences · n=120rct· Ib· Open access· DOI · PMID 21282661	rct	Ib
Azithromycin to prevent COPD exacerbationsAlbert RK, Connett J, Bailey WC · New England Journal of Medicine · n=1,142rct· Ib· Subscription· DOI · PMID 21382995	rct	Ib
Tranexamic acid in trauma hemorrhageCRASH-2 trial collaborators, Roberts I, Shakur H · The Lancet · n=20,211rct· Ia· Subscription· DOI · PMID 21719437	rct	Ia
Topical diclofenac for knee osteoarthritisBarthel HR, Haselwood GM, Klein G · New England Journal of Medicine · n=302rct· Ib· Subscription· DOI · PMID 21428768	rct	Ib

2010

2 entries

Name	Study type	Evidence	Open
Eplerenone in patients with systolic heart failureZannad F, McMurray JJ, Krum H · New England Journal of Medicine · n=3,444rct· Ia· Subscription· DOI · PMID 20660825	rct	Ia
Preexposure prophylaxis for HIV preventionGrant RM, Lama JR, Anderson PL · New England Journal of Medicine · n=2,499rct· Ia· Subscription· DOI · PMID 21672751	rct	Ia

2009

3 entries

Name	Study type	Evidence
Colonoscopy quality and indicationBaxter NN, Sutradhar R, Forgie LM · Annals of Internal Medicinemeta-analysis· IIa· Subscription· DOI · PMID 19704087	meta-analysis	IIa
Denosumab for prevention of fractures in postmenopausal womenCummings SR, Martin JS, McClung MR · New England Journal of Medicine · n=7,868rct· Ia· Subscription· DOI · PMID 19357633	rct	Ia
Dabigatran versus warfarin in atrial fibrillationConnolly SJ, Ezekowitz MD, Yusuf S · New England Journal of Medicine · n=18,201rct· Ia· Subscription· DOI · PMID 19689466	rct	Ia

2007

1 entry

Name	Study type	Evidence	Open
Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression.Wright DC, Han DH, Garcia-Roves PM et al. · n=36other· V· Open access· DOI · PMID 17099248	other	V

2006

4 entries

Name	Study type	Evidence
The effects of capsaicin on energy intake and appetiteLudy MJ, Mattes RD · Obesity · n=25rct· IIb· Subscription· DOI · PMID 16910090	rct	IIb
Citalopram for treatment of major depressionNemeroff CB, Heimsoth DJ, Kristol J · JAMA · n=405rct· Ib· Subscription· DOI · PMID 16439662	rct	Ib
The empirical status of cognitive-behavioral therapyButler AC, Chapman JE, Forman EM · JAMA · n=10,601meta-analysis· Ia· Subscription· DOI · PMID 18511504	meta-analysis	Ia
Ranibizumab for neovascular age-related macular degenerationRosenfeld PJ, Brown DM, Heier JS · New England Journal of Medicine · n=716rct· Ia· Subscription· DOI · PMID 19141437	rct	Ia

2005

2 entries

Name	Study type	Evidence	Open
Physical activity and breast cancer survivalHolmes MD, Chen WY, Feskanich D · JAMA · n=2,987cohort· IIa· Subscription· DOI · PMID 15837700	cohort	IIa
Physical activity and survival after breast cancer diagnosis.Holmes MD, Chen WY, Feskanich D et al. · JAMA · n=2,987cohort· IIa· Subscription· DOI · PMID 15914748	cohort	IIa

2002

2 entries

Name	Study type	Evidence	Open
Therapeutic hypothermia after cardiac arrestBernard SA, Gray TW, Buist MD · New England Journal of Medicine · n=77rct· Ib· Subscription· DOI · PMID 12186607	rct	Ib
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.Knowler WC, Barrett-Connor E, Fowler SE et al. · New England Journal of Medicine · n=3,234rct· Ib· Open access· DOI · PMID 11832527	rct	Ib

2001

1 entry

Name	Study type	Evidence	Open
Early goal-directed therapy for severe sepsis and septic shockRivers E, Nguyen B, Havstad S · New England Journal of Medicine · n=263rct· Ib· Subscription· DOI · PMID 11445681	rct	Ib

1999

1 entry

Name	Study type	Evidence	Open
Randomized trial of alendronate on fracture preventionBlack DM, Cummings SR, Karpf DB · JAMA · n=2,027rct· Ia· Subscription· DOI · PMID 10573304	rct	Ia

1998

1 entry

Name	Study type	Evidence	Open
Metformin and cardiovascular outcomes in type 2 diabetesUK Prospective Diabetes Study Group · The Lancet · n=3,867rct· Ia· Subscription· DOI · PMID 9737553	rct	Ia

1997

1 entry

Name	Study type	Evidence	Open
A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group.Appel LJ, Moore TJ, Obarzanek E et al. · New England Journal of Medicine · n=459rct· Ib· Subscription· DOI · PMID 9099655	rct	Ib

1980

1 entry

Name	Study type	Evidence	Open
Continuous oxygen therapy in COPDNocturnal Oxygen Therapy Trial Group · New England Journal of Medicine · n=203rct· Ib· Subscription· DOI · PMID 83906	rct	Ib