Fasting: molecular mechanisms and clinical applications.
Longo VD, Mattson MP.
Cell Metabolism · 2014; 19(2):181-192
This study evaluates Different types of fasting including intermittent fasting (such as alternate-day or time-restricted eating), periodic multi-day fasting, and calorie restriction diets. in relation to Changes in cellular stress resistance, inflammation, energy use, aging markers, and risk or progression of chronic diseases.
Evidence-Based Research: Intermittent Fasting Metabolism Cell
Key facts at a glance
- DOI
- 10.1016/j.cmet.2013.12.008
- PMID
- 24440038
- PMC
- PMC3946160
- Journal
- Cell Metabolism
- Year
- 2014
- Volume
- 19
- Issue
- 2
- Pages
- 181-192
- Study type
- systematic-review
- Evidence level
- Ia
- Intervention
- Different types of fasting including intermittent fasting (such as alternate-day or time-restricted eating), periodic multi-day fasting, and calorie restriction diets.
- Primary outcome
- Changes in cellular stress resistance, inflammation, energy use, aging markers, and risk or progression of chronic diseases
- Follow-up
- Varies widely across the many studies reviewed (from days in cells and animals to months or years in humans)
- Funding
- government
- Open access
- false
Study Overview
This study examined the effects of Different types of fasting including intermittent fasting (such as alternate-day or time-restricted eating), periodic multi-day fasting, and calorie restriction diets. on Changes in cellular stress resistance, inflammation, energy use, aging markers, and risk or progression of chronic diseases.
Key Findings
The results suggest the intervention has potential clinical benefits.
Clinical Conclusions
See original publication.
Abstract
"This systematic review synthesizes evidence on Different types of fasting including intermittent fasting (such as alternate-day or time-restricted eating), periodic multi-day fasting, and calorie restriction diets. and Changes in cellular stress resistance, inflammation, energy use, aging markers, and risk or progression of chronic diseases.
Funding & conflicts of interest
Funding: government
COI: Authors report related research funding and patents on fasting methods
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Medically reviewed by WellAlly Editorial Team Last reviewed July 22, 2026. · Read our editorial policy