GLP-1受体激动剂治疗阻塞性睡眠呼吸暂停
Malhotra A, Grunstein RR, Fietze I, Weaver TE, Redline S, Azarbarzin A等
New England Journal of Medicine · 2024; 391(13):1193-1205
本综述评估Tirzepatide (maximum tolerated dose of 10 mg or 15 mg) given as a once-weekly injection for 52 weeks, compared with placebo与Change in apnea-hypopnea index (AHI, number of breathing pauses per hour of sleep) from baseline to week 52的关系。纳入 469 例受试者。证据等级：Ib。
循证研究：GLP-1受体激动剂治疗阻塞性睡眠呼吸暂停
关键信息一览
- DOI
- 10.1056/nejmoa2404881
- PMID
- 38912654
- PMC
- PMC11598664
- 期刊
- New England Journal of Medicine
- 年份
- 2024
- 卷
- 391
- 期
- 13
- 页码
- 1193-1205
- 研究类型
- RCT
- 证据等级
- Ib
- 样本量
- 469
- 干预措施
- Tirzepatide (maximum tolerated dose of 10 mg or 15 mg) given as a once-weekly injection for 52 weeks, compared with placebo
- 主要终点
- Change in apnea-hypopnea index (AHI, number of breathing pauses per hour of sleep) from baseline to week 52
- 随访时长
- 52 weeks
- 资金来源
- industry
- 效应量
- AHI reduction difference vs placebo: -20.0 events/h (Trial 1) and -23.8 events/h (Trial 2); mean body weight loss 17-20%
- 注册号
- NCT05412004
- 开放获取
- 是
研究概述
本研究纳入 469 例受试者，探讨了Tirzepatide (maximum tolerated dose of 10 mg or 15 mg) given as a once-weekly injection for 52 weeks, compared with placebo对Change in apnea-hypopnea index (AHI, number of breathing pauses per hour of sleep) from baseline to week 52的影响。
关键发现
研究结果为Change in apnea-hypopnea index (AHI, number of breathing pauses per hour of sleep) from baseline to week 52提供了重要证据。
临床结论
详见原始文献。证据等级：Ib。
Abstract
"本随机对照试验共纳入 469 例受试者，探讨了Tirzepatide (maximum tolerated dose of 10 mg or 15 mg) given as a once-weekly injection for 52 weeks, compared with placebo对Change in apnea-hypopnea index (AHI, number of breathing pauses per hour of sleep) from baseline to week 52的影响。
Funding & conflicts of interest
资金来源: industry
COI: Study sponsored by Eli Lilly; many authors reported consulting fees, research support, or employment ties to Eli Lilly and other pharmaceutical companies
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