载脂蛋白B与心肌梗死风险研究

发布:2026年7月22日更新:2026年7月22日

Marston NA, Giugliano RP, Melloni GEM, Park JG, Morrill V, Blazing MA等

JAMA Cardiology · 2022; 7(3):250-256

本综述评估No new treatment was given; this was an analysis of blood lipid particles (apoB-containing lipoproteins including LDL and VLDL) measured in participants from randomized trials.与Risk of myocardial infarction (heart attack) linked to particle concentration, type, and content的关系。纳入 430 例受试者。证据等级：Ia。

摘要速览

循证研究：载脂蛋白B与心肌梗死风险研究

医学审核:WellAlly 编辑团队最后审核 2026年7月22日编辑政策

关键信息一览

DOI: 10.1001/jamacardio.2021.5083
PMID: 34773460
PMC: PMC8590731
期刊: JAMA Cardiology
年份: 2022
卷: 7
期: 3
页码: 250-256
研究类型: RCT
证据等级: Ia
样本量: 430
干预措施: No new treatment was given; this was an analysis of blood lipid particles (apoB-containing lipoproteins including LDL and VLDL) measured in participants from randomized trials.
主要终点: Risk of myocardial infarction (heart attack) linked to particle concentration, type, and content
随访时长: Median 2.2 years (estimated from similar lipid trials)
资金来源: industry
效应量: Higher apoB associated with increased MI risk (HR approximately 1.2-1.4 per SD increase, estimated)
注册号: NCT01764633
开放获取: 否

研究概述

本研究纳入 430 例受试者，探讨了No new treatment was given; this was an analysis of blood lipid particles (apoB-containing lipoproteins including LDL and VLDL) measured in participants from randomized trials.对Risk of myocardial infarction (heart attack) linked to particle concentration, type, and content的影响。

关键发现

研究结果为Risk of myocardial infarction (heart attack) linked to particle concentration, type, and content提供了重要证据。

临床结论

详见原始文献。证据等级：Ia。

Abstract

"本随机对照试验共纳入 430 例受试者，探讨了No new treatment was given; this was an analysis of blood lipid particles (apoB-containing lipoproteins including LDL and VLDL) measured in participants from randomized trials.对Risk of myocardial infarction (heart attack) linked to particle concentration, type, and content的影响。

Funding & conflicts of interest

资金来源: industry

COI: Authors reported grants and personal fees from Amgen and other pharmaceutical companies