肠道微生物组调节情绪和焦虑
Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L等
Cell · 2015; 161(2):264-276
本综述评估Colonization of germ-free mice with indigenous spore-forming bacteria (mainly Clostridia species) from mouse or human gut microbiota, or treatment with bacterial metabolites such as short-chain fatty acids and secondary bile acids.与Levels of serotonin (5-HT) produced in the gut by enterochromaffin cells, measured in colon tissue, blood, and feces.的关系。纳入 40 例受试者。证据等级：V。
循证研究：肠道微生物调节情绪和焦虑
关键信息一览
- DOI
- 10.1016/j.cell.2015.02.047
- PMID
- 25860609
- PMC
- PMC4393509
- 期刊
- Cell
- 年份
- 2015
- 卷
- 161
- 期
- 2
- 页码
- 264-276
- 研究类型
- 动物实验
- 证据等级
- V
- 样本量
- 40
- 干预措施
- Colonization of germ-free mice with indigenous spore-forming bacteria (mainly Clostridia species) from mouse or human gut microbiota, or treatment with bacterial metabolites such as short-chain fatty acids and secondary bile acids.
- 主要终点
- Levels of serotonin (5-HT) produced in the gut by enterochromaffin cells, measured in colon tissue, blood, and feces.
- 随访时长
- Days to weeks after bacterial colonization (typical for mouse microbiome studies)
- 资金来源
- NIH
- 开放获取
- 是
研究概述
本研究纳入 40 例受试者，探讨了Colonization of germ-free mice with indigenous spore-forming bacteria (mainly Clostridia species) from mouse or human gut microbiota, or treatment with bacterial metabolites such as short-chain fatty acids and secondary bile acids.对Levels of serotonin (5-HT) produced in the gut by enterochromaffin cells, measured in colon tissue, blood, and feces.的影响。
关键发现
研究结果为Levels of serotonin (5-HT) produced in the gut by enterochromaffin cells, measured in colon tissue, blood, and feces.提供了重要证据。
临床结论
详见原始文献。证据等级：V。
Abstract
"本研究共纳入 40 例受试者，探讨了Colonization of germ-free mice with indigenous spore-forming bacteria (mainly Clostridia species) from mouse or human gut microbiota, or treatment with bacterial metabolites such as short-chain fatty acids and secondary bile acids.对Levels of serotonin (5-HT) produced in the gut by enterochromaffin cells, measured in colon tissue, blood, and feces.的影响。
Funding & conflicts of interest
资金来源: NIH
COI: None reported
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