肠道微生物组介导生酮饮食的抗癫痫作用
Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY.
· 2018:1728-1741.e13
本综述评估Ketogenic diet (high-fat, low-carbohydrate) versus control diet, combined with gut microbiota changes such as antibiotics, germ-free rearing, and bacterial transplants与Protection against acute electrically induced seizures and spontaneous tonic-clonic seizures的关系。纳入 100 例受试者。证据等级：V。
循证研究：生酮饮食通过肠道微生物介导抗癫痫作用
关键信息一览
- DOI
- 10.1016/j.cell.2018.04.027
- PMID
- 29804833
- PMC
- PMC6003870
- 年份
- 2018
- 页码
- 1728-1741.e13
- 研究类型
- 动物实验
- 证据等级
- V
- 样本量
- 100
- 干预措施
- Ketogenic diet (high-fat, low-carbohydrate) versus control diet, combined with gut microbiota changes such as antibiotics, germ-free rearing, and bacterial transplants
- 主要终点
- Protection against acute electrically induced seizures and spontaneous tonic-clonic seizures
- 随访时长
- Days to several weeks (acute and short-term models)
- 资金来源
- government
- 开放获取
- 是
研究概述
本研究纳入 100 例受试者，探讨了Ketogenic diet (high-fat, low-carbohydrate) versus control diet, combined with gut microbiota changes such as antibiotics, germ-free rearing, and bacterial transplants对Protection against acute electrically induced seizures and spontaneous tonic-clonic seizures的影响。
关键发现
研究结果为Protection against acute electrically induced seizures and spontaneous tonic-clonic seizures提供了重要证据。
临床结论
详见原始文献。证据等级：V。
Abstract
"本研究共纳入 100 例受试者，探讨了Ketogenic diet (high-fat, low-carbohydrate) versus control diet, combined with gut microbiota changes such as antibiotics, germ-free rearing, and bacterial transplants对Protection against acute electrically induced seizures and spontaneous tonic-clonic seizures的影响。
Funding & conflicts of interest
资金来源: government
COI: None reported
本信息仅供教育用途，不能替代专业医疗建议、诊断或治疗。
本内容仅供一般信息和教育用途，不能替代专业医疗建议、诊断或治疗。对于任何医疗问题，请务必咨询合格的医疗服务提供者；切勿因阅读本站内容而忽视专业医疗建议或推迟就医。
如果您认为自己可能出现医疗紧急情况，请立即拨打当地急救电话或前往最近的急诊科。
医学审核:WellAlly 编辑团队 最后审核 2026年7月22日. · 阅读我们的编辑政策