Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting.
Singh I, Bhat S, Tamatta R, Singh AK.
· 2026:75
This study evaluates Intermittent fasting (various patterns such as time-restricted eating) as a lifestyle approach to influence cellular cleanup and aging processes in relation to Changes in autophagy activity, cellular senescence markers, and markers of brain aging or neurodegeneration risk.
Evidence-Based Research: Fmd Aging Clocks Biorxiv
Key facts at a glance
- DOI
- 10.1007/s10571-026-01709-7
- PMID
- 41811567
- PMC
- PMC13018527
- Year
- 2026
- Pages
- 75
- Study type
- other
- Evidence level
- V
- Intervention
- Intermittent fasting (various patterns such as time-restricted eating) as a lifestyle approach to influence cellular cleanup and aging processes
- Primary outcome
- Changes in autophagy activity, cellular senescence markers, and markers of brain aging or neurodegeneration risk
- Follow-up
- Not applicable (narrative review of prior research)
- Funding
- unknown
- Open access
- false
Study Overview
This study examined the effects of Intermittent fasting (various patterns such as time-restricted eating) as a lifestyle approach to influence cellular cleanup and aging processes on Changes in autophagy activity, cellular senescence markers, and markers of brain aging or neurodegeneration risk.
Key Findings
The results suggest the intervention has potential clinical benefits.
Clinical Conclusions
See original publication.
Abstract
"This study synthesizes evidence on Intermittent fasting (various patterns such as time-restricted eating) as a lifestyle approach to influence cellular cleanup and aging processes and Changes in autophagy activity, cellular senescence markers, and markers of brain aging or neurodegeneration risk.
Funding & conflicts of interest
Funding: unknown
COI: None reported
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Medically reviewed by WellAlly Editorial Team Last reviewed July 22, 2026. · Read our editorial policy