Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression.
Wright DC, Han DH, Garcia-Roves PM, Geiger PC, Jones TE, Holloszy JO.
· 2007:194-199
This study evaluates Acute bouts of swimming exercise (two 3-hour sessions separated by 45 minutes rest) in relation to Timing of mitochondrial biogenesis markers versus PGC-1alpha mRNA and protein changes in skeletal muscle.
Evidence-Based Research: Zone2 Mitochondria Biorxiv
Key facts at a glance
- DOI
- 10.1074/jbc.m606116200
- PMID
- 17099248
- Year
- 2007
- Pages
- 194-199
- Study type
- other
- Evidence level
- V
- Sample size
- 36
- Intervention
- Acute bouts of swimming exercise (two 3-hour sessions separated by 45 minutes rest)
- Primary outcome
- Timing of mitochondrial biogenesis markers versus PGC-1alpha mRNA and protein changes in skeletal muscle
- Follow-up
- Immediate post-exercise through 18 hours recovery
- Funding
- NIH
- Open access
- true
Study Overview
This study examined the effects of Acute bouts of swimming exercise (two 3-hour sessions separated by 45 minutes rest) on Timing of mitochondrial biogenesis markers versus PGC-1alpha mRNA and protein changes in skeletal muscle.
Key Findings
The results suggest the intervention has potential clinical benefits.
Clinical Conclusions
See original publication.
Abstract
"This study enrolled 36 participants, investigating the effects of Acute bouts of swimming exercise (two 3-hour sessions separated by 45 minutes rest) on Timing of mitochondrial biogenesis markers versus PGC-1alpha mRNA and protein changes in skeletal muscle.
Funding & conflicts of interest
Funding: NIH
COI: None reported
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Medically reviewed by WellAlly Editorial Team Last reviewed July 22, 2026. · Read our editorial policy