Complications of long-term PPI use
Vaezi MF, Yang YX, Howden CW
New England Journal of Medicine · 2017
This meta-analysis evaluates the intervention under study in relation to the primary clinical outcome. Includes 5,330,000 participants. Evidence level: IIa.
循证研究：长期PPI使用并发症
Key facts at a glance
- DOI
- 10.1056/NEJMoa1702507
- PMID
- 29460633
- Journal
- New England Journal of Medicine
- Year
- 2017
- Study type
- meta-analysis
- Evidence level
- IIa
- Sample size
- 5330000
- Intervention
- PPI 长期使用
- Primary outcome
- 骨折、骨病、肾损伤、感染
- Open access
- false
Study Overview
This meta-analysis enrolled 5,330,000 participants and examined the primary clinical outcome.
Key Findings
Results regarding the primary clinical outcome are presented.
Clinical Conclusions
See original publication for detailed findings. Evidence level: IIa.
Abstract
"This meta-analysis enrolled 5,330,000 participants, investigating the effects of PPI 长期使用 on 骨折、骨病、肾损伤、感染.
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Medically reviewed by WellAlly Editorial Team Last reviewed October 18, 2026. · Read our editorial policy