生活方式干预或二甲双胍减少2型糖尿病发病率

发布:2026年7月22日更新:2026年7月22日

Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA等

New England Journal of Medicine · 2002; 346(6):393-403

本综述评估Intensive lifestyle program (low-calorie low-fat diet plus at least 150 minutes of moderate exercise per week aiming for 7% weight loss) or metformin 850 mg twice daily, each compared with placebo pills.与New cases of type 2 diabetes的关系。纳入 3,234 例受试者。证据等级：Ib。

摘要速览

循证研究：二甲双胍减少2型糖尿病发病

医学审核:WellAlly 编辑团队最后审核 2026年7月22日编辑政策

关键信息一览

DOI: 10.1056/nejmoa012512
PMID: 11832527
PMC: PMC1370926
期刊: New England Journal of Medicine
年份: 2002
卷: 346
期: 6
页码: 393-403
研究类型: RCT
证据等级: Ib
样本量: 3234
干预措施: Intensive lifestyle program (low-calorie low-fat diet plus at least 150 minutes of moderate exercise per week aiming for 7% weight loss) or metformin 850 mg twice daily, each compared with placebo pills.
主要终点: New cases of type 2 diabetes
随访时长: 2.8 years average
资金来源: NIH
效应量: Lifestyle reduced diabetes risk by 58% (95% CI 48-66%); metformin reduced it by 31% (95% CI 17-43%) vs placebo
注册号: NCT00004992
开放获取: 是

研究概述

本研究纳入 3,234 例受试者，探讨了Intensive lifestyle program (low-calorie low-fat diet plus at least 150 minutes of moderate exercise per week aiming for 7% weight loss) or metformin 850 mg twice daily, each compared with placebo pills.对New cases of type 2 diabetes的影响。

关键发现

研究结果为New cases of type 2 diabetes提供了重要证据。

临床结论

详见原始文献。证据等级：Ib。

Abstract

"本随机对照试验共纳入 3,234 例受试者，探讨了Intensive lifestyle program (low-calorie low-fat diet plus at least 150 minutes of moderate exercise per week aiming for 7% weight loss) or metformin 850 mg twice daily, each compared with placebo pills.对New cases of type 2 diabetes的影响。

Funding & conflicts of interest

资金来源: NIH

COI: None reported