Randomized trial of alendronate on fracture prevention
Black DM, Cummings SR, Karpf DB
JAMA · 1999
This randomized controlled trial evaluates the intervention under study in relation to the primary clinical outcome. Includes 2,027 participants. Evidence level: Ia.
循证研究：阿仑膦酸钠预防骨折
Key facts at a glance
- DOI
- 10.1001/jama.282.14.1344
- PMID
- 10573304
- Journal
- JAMA
- Year
- 1999
- Study type
- rct
- Evidence level
- Ia
- Sample size
- 2027
- Intervention
- 阿仑膦酸钠 10mg/天 vs 安慰剂
- Primary outcome
- 椎体和非椎体骨折发生率
- Open access
- false
Study Overview
This randomized controlled trial enrolled 2,027 participants and examined the primary clinical outcome.
Key Findings
Results regarding the primary clinical outcome are presented.
Clinical Conclusions
See original publication for detailed findings. Evidence level: Ia.
Abstract
"This randomized controlled trial enrolled 2,027 participants, investigating the effects of 阿仑膦酸钠 10mg/天 vs 安慰剂 on 椎体和非椎体骨折发生率.
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Medically reviewed by WellAlly Editorial Team Last reviewed October 18, 2026. · Read our editorial policy