Topical diclofenac for knee osteoarthritis
Barthel HR, Haselwood GM, Klein G
New England Journal of Medicine · 2011
This randomized controlled trial evaluates the intervention under study in relation to the primary clinical outcome. Includes 302 participants. Evidence level: Ib.
循证研究：外用NSAIDs治疗膝关节骨关节炎
Key facts at a glance
- DOI
- 10.1056/NEJMoa1109794
- PMID
- 21428768
- Journal
- New England Journal of Medicine
- Year
- 2011
- Study type
- rct
- Evidence level
- Ib
- Sample size
- 302
- Intervention
- 外用双氯芬酸凝胶 vs 口服塞来昔布 vs 安慰剂
- Primary outcome
- WOMAC疼痛和功能评分
- Open access
- false
Study Overview
This randomized controlled trial enrolled 302 participants and examined the primary clinical outcome.
Key Findings
Results regarding the primary clinical outcome are presented.
Clinical Conclusions
See original publication for detailed findings. Evidence level: Ib.
Abstract
"This randomized controlled trial enrolled 302 participants, investigating the effects of 外用双氯芬酸凝胶 vs 口服塞来昔布 vs 安慰剂 on WOMAC疼痛和功能评分.
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Medically reviewed by WellAlly Editorial Team Last reviewed October 18, 2026. · Read our editorial policy