A phase 3 trial of pirfenidone in idiopathic pulmonary fibrosis
King TE, Bradford WZ, Castro-Bernardini S
New England Journal of Medicine · 2014
This randomized controlled trial evaluates the intervention under study in relation to the primary clinical outcome. Includes 555 participants. Evidence level: Ia.
循证研究：Pirfenidone治疗特发性肺纤维化
Key facts at a glance
- DOI
- 10.1056/NEJMoa1402584
- PMID
- 24836310
- Journal
- New England Journal of Medicine
- Year
- 2014
- Study type
- rct
- Evidence level
- Ia
- Sample size
- 555
- Intervention
- Pirfenidone 2403mg/天 vs 安慰剂
- Primary outcome
- FVC 变化
- Open access
- false
Study Overview
This randomized controlled trial enrolled 555 participants and examined the primary clinical outcome.
Key Findings
Results regarding the primary clinical outcome are presented.
Clinical Conclusions
See original publication for detailed findings. Evidence level: Ia.
Abstract
"This randomized controlled trial enrolled 555 participants, investigating the effects of Pirfenidone 2403mg/天 vs 安慰剂 on FVC 变化.
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Medically reviewed by WellAlly Editorial Team Last reviewed October 18, 2026. · Read our editorial policy