A Randomized Trial of Intensive versus Standard Blood-Pressure Control.

Published: July 22, 2026Updated: July 22, 2026

SPRINT Research Group, Wright JT, Williamson JD, Whelton PK, Snyder JK, Sink KMet al.

New England Journal of Medicine · 2015; 373(22):2103-2116

This randomized controlled trial evaluates the intervention under study in relation to the primary clinical outcome. Includes 9,361 participants. Evidence level: Ib.

Quick summary

循证研究：强化血压控制 vs 标准血压控制

Medically reviewed by WellAlly Editorial TeamLast reviewed July 22, 2026Editorial policy

Key facts at a glance

DOI: 10.1056/nejmoa1511939
PMID: 26551272
PMC: PMC4689591
Journal: New England Journal of Medicine
Year: 2015
Volume: 373
Issue: 22
Pages: 2103-2116
Study type: rct
Evidence level: Ib
Sample size: 9361
Intervention: Intensive systolic blood-pressure target of less than 120 mm Hg versus standard target of less than 140 mm Hg, achieved mainly with common blood-pressure medications
Primary outcome: Composite of myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes
Follow-up: 3.26 years median
Funding: NIH
Effect size: HR 0.75 (95% CI 0.64-0.89), p<0.001 for primary outcome; all-cause mortality HR 0.73 (95% CI 0.60-0.90)
Registration: NCT01206062
Open access: true

Study Overview

This randomized controlled trial enrolled 9,361 participants and examined the primary clinical outcome.

Key Findings

Results regarding the primary clinical outcome are presented.

Clinical Conclusions

See original publication for detailed findings. Evidence level: Ib.

Abstract

"This randomized controlled trial enrolled 9,361 participants, investigating the effects of Intensive systolic blood-pressure target of less than 120 mm Hg versus standard target of less than 140 mm Hg, achieved mainly with common blood-pressure medications on Composite of myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes.

Funding & conflicts of interest

Funding: NIH

COI: Some authors reported consulting fees or grants from industry; overall study funded by government

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Medically reviewed by WellAlly Editorial Team Last reviewed July 22, 2026. · Read our editorial policy