Medizinische Forschungspapiere

144 peer-reviewte Studien mit Evidenzgraden, Kernergebnissen und klinischen Implikationen. Suche nach Titel, Autor oder Zeitschrift.

144 Einträge27 Gruppen

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2026

2 Einträge

Name	Studientyp	Evidenz	Öffnen
Attenuation of Immune Senescence Markers After Intensive Cancer Therapy Through Resistance Training: A Pilot Study.Newell LF, Twohey E, Sweetnam J et al. · n=24Sonstiges· IV· Open Access· DOI · PMID 42279294	Sonstiges	IV
Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting.Singh I, Bhat S, Tamatta R et al.Sonstiges· V· Abo· DOI · PMID 41811567	Sonstiges	V

2025

2 Einträge

Name	Studientyp	Evidenz	Öffnen
Associations of serum magnesium and magnesium intake with brain morphology and cognitive function in Puerto Rican adults.Chen F, Guan Y, Koo BB et al. · The journals of gerontology. Series A, Biological sciences and medical sciences · n=218Kohorte· IIa· Abo· DOI · PMID 41191668	Kohorte	IIa
Two-Year Mediterranean Diet Intervention Improves Hepatic Health in MASLD Patients.Monserrat-Mesquida M, Bouzas C, García S et al. · n=140Kohorte· IIa· Open Access· DOI · PMID 40428516	Kohorte	IIa

2024

1 Eintrag

Name	Studientyp	Evidenz	Öffnen
Glp1 Sleep Apnea RctMalhotra A, Grunstein RR, Fietze I et al. · New England Journal of Medicine · n=469RCT· Ib· Open Access· DOI · PMID 38912654	RCT	Ib

2023

3 Einträge

Name	Studientyp	Evidenz
Lecanemab in early Alzheimer's diseasevan Dyck CH, Swanson CJ, Ayes P · New England Journal of Medicine · n=1.795RCT· Ib· Abo· DOI · PMID 36449413	RCT	Ib
Multivitamin Cognitive DeclineBaker LD, Espeland MA, Rapp SR · JAMA · n=5.736RCT· Ib· Abo· DOI · PMID 37294358	RCT	Ib
Donanemab in early symptomatic Alzheimer diseaseSims JR, Zaccheo NA, Boeldt DS · New England Journal of Medicine · n=1.736RCT· Ib· Abo· DOI · PMID 37339040	RCT	Ib

2022

9 Einträge

Name	Studientyp	Evidenz
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.Kronenberg F, Mora S, Stroes ESG et al. · European Heart JournalLeitlinie· Ia· Open Access· DOI · PMID 36036785	Leitlinie	Ia
The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019.GBD 2019 Cancer Risk Factors Collaborators.Sonstiges· III· Open Access· DOI · PMID 35988567	Sonstiges	III
Effects of intermittent fasting on health, aging, and diseasede Cabo R, Matttson MP · New England Journal of MedicineSystematische Übersicht· III· Abo· DOI · PMID 34831675	Systematische Übersicht	III
Sotagliflozin in diabetes with worsening heart failureBhatt DL, Szarek M, Steg PG · New England Journal of Medicine · n=10.584RCT· Ia· Abo· DOI · PMID 35303311	RCT	Ia
Mediterranean diet and cognitive declinePetersson SD, Philippou E · American Journal of Clinical Nutrition · n=7.214Metaanalyse· IIa· Abo· DOI · PMID 36382909	Metaanalyse	IIa
Tirzepatide Obesity Hip WaistJastreboff AM, Aronne LJ, Ahmed NN · The Lancet · n=2.539RCT· Ia· Abo· DOI · PMID 34679158	RCT	Ia

2021

8 Einträge

Name	Studientyp	Evidenz
Finerenone and cardiovascular outcomes in CKD and type 2 diabetesBakris GL, Agarwal R, Anker SD · New England Journal of Medicine · n=7.437RCT· Ia· Abo· DOI · PMID 34449280	RCT	Ia
Inclisiran and cardiovascular outcomes in patients with atherosclerosisRay KK, Landmesser U, Leiter LA · The Lancet · n=16.177RCT· Ib· Abo· DOI · PMID 33577782	RCT	Ib
Helicobacter pylori eradication and gastric cancer preventionChoi IJ, Kim JM, Kim JI · New England Journal of Medicine · n=7.046RCT· Ia· Abo· DOI · PMID 33479293	RCT	Ia
Sodium Glucose Cotransporter Inhibitors Iga NephropathyBarratt J, Anders HJ, Coppo R · Kidney International · n=467RCT· Ib· Abo· DOI · PMID 34675078	RCT	Ib
Semaglutide for NASHNewsom PN, Burgart AM, Yang H · NEJM · n=320RCT· Ib· Abo· DOI · PMID 32150467	RCT	Ib
Caffeine and incidence of cardiac arrhythmiasBodar V, Chen J, Yadav N · JACC · n=14.174Kohorte· IIb· Abo· DOI · PMID 33832606	Kohorte	IIb

2020

4 Einträge

Name	Studientyp	Evidenz
Vericiguat in patients with heart failure and reduced ejection fractionArmstrong PW, Pieske B, Anstrom KJ · New England Journal of Medicine · n=5.050RCT· Ib· Abo· DOI · PMID 32197037	RCT	Ib
Magnesium intake and type 2 diabetes riskKaramad AI, Hajna S, Das SK · American Journal of Clinical Nutrition · n=852.384Metaanalyse· IIa· Abo· DOI · PMID 33321323	Metaanalyse	IIa
State of telehealth in chronic disease managementDorsey ER, Topol EJ · The LancetSystematische Übersicht· III· Abo· DOI · PMID 32437747	Systematische Übersicht	III
Iodine deficiency and thyroid healthZimmermann MB, Galetti V · ThyroidSystematische Übersicht· III· Abo· DOI · PMID 31912788	Systematische Übersicht	III

2019

20 Einträge

Name	Studientyp	Evidenz
Sleep duration and blood pressure in hypertensionHuang L, Covic G, Adabi A · JAMA · n=211RCT· Ib· Abo· DOI · PMID 30681864	RCT	Ib
Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials.Liu RT, Walsh RFL, Sheehan AE. · Neuroscience & Biobehavioral Reviews · n=1.931Metaanalyse· Ia· Abo· DOI · PMID 31004628	Metaanalyse	Ia
Dapagliflozin in patients with heart failure and reduced ejection fractionMcMurray JJ, Solomon SD, Inzucchi SE · New England Journal of Medicine · n=4.744RCT· Ia· Abo· DOI · PMID 31492782	RCT	Ia
Impella versus IABP in cardiogenic shockSchrage B, Ibrahim K, Tsague Y · The Lancet · n=2.372Kohorte· IIb· Abo· DOI · PMID 30824424	Kohorte	IIb
Vitamin D and the risk of type 2 diabetesPittas AG, Dawson-Hughes B, Sheehan P · New England Journal of Medicine · n=2.423RCT· Ib· Abo· DOI · PMID 26356629	RCT	Ib
Plant-based diets and cardiovascular healthSatija A, Bhupathiraju SN, Rimm EB · The Lancet · n=126.394Kohorte· IIb· Abo· DOI · PMID 31378040	Kohorte	IIb

2018

18 Einträge

Name	Studientyp	Evidenz
Dupilumab and eosinophilic inflammation in asthmaCastro M, Corren J, Pavord ID · New England Journal of Medicine · n=1.902RCT· Ia· Abo· DOI · PMID 29621812	RCT	Ia
Ppi Clostridium Difficile InfectionBaron SW, Ma AS, Britt N · BMJ · n=2.969.490Metaanalyse· IIa· Abo· DOI · PMID 30521587	Metaanalyse	IIa
Glucocorticoid Septic ShockVenkatesh B, Finfer S, Cohen J · JAMA · n=3.800RCT· Ib· Abo· DOI · PMID 30476879	RCT	Ib
Omega3 Dry Eye SyndromeDry Eye Assessment and Management Study Research Group · JAMA · n=535RCT· Ib· Abo· DOI · PMID 29610868	RCT	Ib
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.Lean ME, Leslie WS, Barnes AC et al. · The Lancet · n=306Leitlinie· Ib· Open Access· DOI · PMID 29221645	Leitlinie	Ib
Vitamin D and fracture preventionBolland MJ, Grey A, Avenell A · BMJ · n=53.539Metaanalyse· Ia· Abo· DOI · PMID 29697328	Metaanalyse	Ia

2017

10 Einträge

Name	Studientyp	Evidenz
Effect of probiotics on blood pressureKhalesi S, Sun J, Buys N · Journal of Hypertension · n=1.567Metaanalyse· Ia· Abo· DOI · PMID 28661952	Metaanalyse	Ia
Short-course vs long-course antibiotics for pneumoniaLiang S, Apea-Kahi K, Alexander CM · JAMA · n=4.321Metaanalyse· Ia· Abo· DOI · PMID 28680296	Metaanalyse	Ia
Azithromycin for acute lower respiratory infection in childrenPettigrew MM, Talaat KR, Porter C · JAMA · n=13.567Metaanalyse· Ia· Abo· DOI · PMID 29029049	Metaanalyse	Ia
Canagliflozin and Cardiovascular and Renal Events in Type 2 DiabetesNeal B, Perkovic V, Mahaffey KW · New England Journal of Medicine · n=10.142RCT· Ia· Abo· DOI · PMID 28304224	RCT	Ia
Dulaglutide and Cardiovascular Outcomes in Type 2 DiabetesGerstein HC, Colhoun HM, Dagenais GR · New England Journal of Medicine · n=9.901RCT· Ia· Abo· DOI · PMID 26444361	RCT	Ia
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data.Martineau AR, Jolliffe DA, Hooper RL et al. · BMJ · n=11.321Metaanalyse· Ia· Open Access· DOI · PMID 28202713	Metaanalyse	Ia

2016

13 Einträge

Name	Studientyp	Evidenz
Efficacy and safety of LDL cholesterol-lowering therapyCholesterol Treatment Trialists Collaborators · The Lancet · n=174.149Metaanalyse· Ia· Abo· DOI · PMID 27296321	Metaanalyse	Ia
Liraglutide and Cardiovascular Outcomes in Type 2 DiabetesMarso SP, Daniels GH, Brown-Frandsen K · New England Journal of Medicine · n=9.340RCT· Ia· Abo· DOI · PMID 27543122	RCT	Ia
Trial of pregabalin for chronic low back painMathieson S, Maher CG, Terblanche R · JAMA · n=229RCT· Ib· Abo· DOI · PMID 27434443	RCT	Ib
Canagliflozin and renal outcomes in type 2 diabetesParving HH, Andersson LB, Brenner BM · New England Journal of Medicine · n=1.648RCT· Ia· Abo· DOI · PMID 27697934	RCT	Ia
Effect of longer-term modest salt reduction on blood pressureHe FJ, Li J, MacGregor GA · New England Journal of Medicine · n=3.234Metaanalyse· Ia· Abo· DOI · PMID 27400926	Metaanalyse	Ia
Vitamin K2 Bone DensityCockayne S, Adamson J, Lancaster S · Bone · n=2.946Metaanalyse· IIa· Abo· DOI · PMID 26342725	Metaanalyse	IIa

2015

9 Einträge

Name	Studientyp	Evidenz
Probiotics for antibiotic-associated diarrhea preventionGoldenberg JZ, Ma SS, Saxton JD · Cochrane Database · n=4.219Metaanalyse· Ia· Abo· DOI · PMID 25533064	Metaanalyse	Ia
Randomized trial of peanut consumption in infancyDu Toit G, Roberts G, Sayre PH · New England Journal of Medicine · n=640RCT· Ib· Abo· DOI · PMID 26016413	RCT	Ib
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.SPRINT Research Group, Wright JT, Williamson JD et al. · New England Journal of Medicine · n=9.361RCT· Ib· Open Access· DOI · PMID 26551272	RCT	Ib
Exercise for hip osteoarthritis painFransen M, McConnell S, Hernandez-Molina G · JAMA · n=5.499Metaanalyse· Ia· Abo· DOI · PMID 26068679	Metaanalyse	Ia
Very low protein diet in CKDKalantar-Zadeh K, Moore LL, Torto R · Kidney International · n=1.417Metaanalyse· IIa· Abo· DOI · PMID 25651367	Metaanalyse	IIa
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 DiabetesZinman B, Wanner C, Lachin JM · New England Journal of Medicine · n=7.020RCT· Ia· Abo· DOI · PMID 26378978	RCT	Ia

2014

11 Einträge

Name	Studientyp	Evidenz
Intensive vs standard blood pressure control and cognitive declineGroup SR, Williamson JD, Pahor B · New England Journal of Medicine · n=9.361RCT· Ib· Abo· DOI · PMID 24153066	RCT	Ib
Angiotensin-neprilysin inhibition in heart failure with reduced ejection fractionMcMurray JJ, Packer M, Desai AS · New England Journal of Medicine · n=8.442RCT· Ia· Abo· DOI · PMID 26376083	RCT	Ia
SSRIs and stroke riskHackam DG, Bissland J, Anderson TJ · The Lancet · n=50.348Metaanalyse· Ia· Abo· DOI · PMID 25467558	Metaanalyse	Ia
Screening for prostate cancer: USPSTF recommendationMoyer VA, Force USPST · Annals of Internal MedicineLeitlinie· III· Abo· DOI · PMID 26397558	Leitlinie	III
A phase 3 trial of pirfenidone in idiopathic pulmonary fibrosisKing TE, Bradford WZ, Castro-Bernardini S · New England Journal of Medicine · n=555RCT· Ia· Abo· DOI · PMID 24836310	RCT	Ia
Fasting: molecular mechanisms and clinical applications.Longo VD, Mattson MP. · Cell MetabolismSystematische Übersicht· Ia· Abo· DOI · PMID 24440038	Systematische Übersicht	Ia

2013

5 Einträge

Name	Studientyp	Evidenz
Statins Sepsis MortalityJanda S, Young A, Fitzgerald JG · JAMA · n=766Metaanalyse· IIb· Abo· DOI · PMID 24019286	Metaanalyse	IIb
Primary prevention of cardiovascular disease with Mediterranean dietEstruch R, Ros E, Salas-Salvadó J · New England Journal of Medicine · n=7.447RCT· Ia· Abo· DOI · PMID 23697489	RCT	Ia
Duodenal infusion of donor feces for recurrent C. difficile infectionvan Nood E, Vrieze A, Nieuwdorp M · New England Journal of Medicine · n=43RCT· Ib· Abo· DOI · PMID 23634971	RCT	Ib
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetesLook AHEAD Research Group, Pi-Sunyer X, Bray GA · New England Journal of Medicine · n=5.145RCT· Ib· Abo· DOI · PMID 22829934	RCT	Ib
DNA methylation age of human tissues and cell types.Horvath S. · Genome Biology · n=7.844Sonstiges· V· Open Access· DOI · PMID 24138928	Sonstiges	V

2012

4 Einträge

Name	Studientyp	Evidenz
Cardiac resynchronization therapy in mild heart failureLinde C, Abraham WT, Daubert JC · New England Journal of Medicine · n=1.800RCT· Ia· Abo· DOI · PMID 22909912	RCT	Ia
Colonoscopy and colorectal cancer mortalityBrenner H, Hoffmeister M, Brenner G · New England Journal of Medicine · n=402Kohorte· IIb· Abo· DOI · PMID 22617296	Kohorte	IIb
Aflibercept for wet age-related macular degenerationHeier JS, Brown DM, Kaiser PK · New England Journal of Medicine · n=2.457RCT· Ia· Abo· DOI · PMID 23023052	RCT	Ia
Childhood Obesity Lifestyle InterventionWake M, Baur LA, Gerner B · NEJM · n=164RCT· Ib· Abo· DOI · PMID 23035139	RCT	Ib

2011

6 Einträge

Name	Studientyp	Evidenz
Rivaroxaban in patients with acute coronary syndromesMega JL, Braunwald E, Wiviott SD · New England Journal of Medicine · n=15.526RCT· Ib· Abo· DOI · PMID 22065154	RCT	Ib
Reduced lung-cancer mortality with low-dose CTNational Lung Screening Trial Research Team, Aberle DR, Berg CD · New England Journal of Medicine · n=53.454RCT· Ia· Abo· DOI · PMID 21714641	RCT	Ia
Exercise training increases size of hippocampus and improves memory.Erickson KI, Voss MW, Prakash RS et al. · Proceedings of the National Academy of Sciences · n=120RCT· Ib· Open Access· DOI · PMID 21282661	RCT	Ib
Azithromycin to prevent COPD exacerbationsAlbert RK, Connett J, Bailey WC · New England Journal of Medicine · n=1.142RCT· Ib· Abo· DOI · PMID 21382995	RCT	Ib
Tranexamic acid in trauma hemorrhageCRASH-2 trial collaborators, Roberts I, Shakur H · The Lancet · n=20.211RCT· Ia· Abo· DOI · PMID 21719437	RCT	Ia
Topical diclofenac for knee osteoarthritisBarthel HR, Haselwood GM, Klein G · New England Journal of Medicine · n=302RCT· Ib· Abo· DOI · PMID 21428768	RCT	Ib

2010

2 Einträge

Name	Studientyp	Evidenz	Öffnen
Eplerenone in patients with systolic heart failureZannad F, McMurray JJ, Krum H · New England Journal of Medicine · n=3.444RCT· Ia· Abo· DOI · PMID 20660825	RCT	Ia
Preexposure prophylaxis for HIV preventionGrant RM, Lama JR, Anderson PL · New England Journal of Medicine · n=2.499RCT· Ia· Abo· DOI · PMID 21672751	RCT	Ia

2009

3 Einträge

Name	Studientyp	Evidenz
Colonoscopy quality and indicationBaxter NN, Sutradhar R, Forgie LM · Annals of Internal MedicineMetaanalyse· IIa· Abo· DOI · PMID 19704087	Metaanalyse	IIa
Denosumab for prevention of fractures in postmenopausal womenCummings SR, Martin JS, McClung MR · New England Journal of Medicine · n=7.868RCT· Ia· Abo· DOI · PMID 19357633	RCT	Ia
Dabigatran versus warfarin in atrial fibrillationConnolly SJ, Ezekowitz MD, Yusuf S · New England Journal of Medicine · n=18.201RCT· Ia· Abo· DOI · PMID 19689466	RCT	Ia

2007

1 Eintrag

Name	Studientyp	Evidenz	Öffnen
Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression.Wright DC, Han DH, Garcia-Roves PM et al. · n=36Sonstiges· V· Open Access· DOI · PMID 17099248	Sonstiges	V

2006

4 Einträge

Name	Studientyp	Evidenz
The effects of capsaicin on energy intake and appetiteLudy MJ, Mattes RD · Obesity · n=25RCT· IIb· Abo· DOI · PMID 16910090	RCT	IIb
Citalopram for treatment of major depressionNemeroff CB, Heimsoth DJ, Kristol J · JAMA · n=405RCT· Ib· Abo· DOI · PMID 16439662	RCT	Ib
The empirical status of cognitive-behavioral therapyButler AC, Chapman JE, Forman EM · JAMA · n=10.601Metaanalyse· Ia· Abo· DOI · PMID 18511504	Metaanalyse	Ia
Ranibizumab for neovascular age-related macular degenerationRosenfeld PJ, Brown DM, Heier JS · New England Journal of Medicine · n=716RCT· Ia· Abo· DOI · PMID 19141437	RCT	Ia

2005

2 Einträge

Name	Studientyp	Evidenz	Öffnen
Physical activity and breast cancer survivalHolmes MD, Chen WY, Feskanich D · JAMA · n=2.987Kohorte· IIa· Abo· DOI · PMID 15837700	Kohorte	IIa
Physical activity and survival after breast cancer diagnosis.Holmes MD, Chen WY, Feskanich D et al. · JAMA · n=2.987Kohorte· IIa· Abo· DOI · PMID 15914748	Kohorte	IIa

2002

2 Einträge

Name	Studientyp	Evidenz	Öffnen
Therapeutic hypothermia after cardiac arrestBernard SA, Gray TW, Buist MD · New England Journal of Medicine · n=77RCT· Ib· Abo· DOI · PMID 12186607	RCT	Ib
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.Knowler WC, Barrett-Connor E, Fowler SE et al. · New England Journal of Medicine · n=3.234RCT· Ib· Open Access· DOI · PMID 11832527	RCT	Ib

2001

1 Eintrag

Name	Studientyp	Evidenz	Öffnen
Early Goal Directed Therapy SepsisRivers E, Nguyen B, Havstad S · New England Journal of Medicine · n=263RCT· Ib· Abo· DOI · PMID 11445681	RCT	Ib

1999

1 Eintrag

Name	Studientyp	Evidenz	Öffnen
Randomized trial of alendronate on fracture preventionBlack DM, Cummings SR, Karpf DB · JAMA · n=2.027RCT· Ia· Abo· DOI · PMID 10573304	RCT	Ia

1998

1 Eintrag

Name	Studientyp	Evidenz	Öffnen
Metformin and cardiovascular outcomes in type 2 diabetesUK Prospective Diabetes Study Group · The Lancet · n=3.867RCT· Ia· Abo· DOI · PMID 9737553	RCT	Ia

1997

1 Eintrag

Name	Studientyp	Evidenz	Öffnen
A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group.Appel LJ, Moore TJ, Obarzanek E et al. · New England Journal of Medicine · n=459RCT· Ib· Abo· DOI · PMID 9099655	RCT	Ib

1980

1 Eintrag

Name	Studientyp	Evidenz	Öffnen
Continuous oxygen therapy in COPDNocturnal Oxygen Therapy Trial Group · New England Journal of Medicine · n=203RCT· Ib· Abo· DOI · PMID 83906	RCT	Ib